Life Science Trace Detection Laboratory

The Life Science Trace Detection Laboratory or TDLab (part of Analytical Chemistry and Chemometrics) operates a variety of state-of-the-art trace gas detectors that allow real time measurements with detection levels at or below parts per billion volume level. 

The experiments offer high temporal and spatial resolution, so that fast reactions of biological material become directly observable. The laboratory is available to internal and external users.

To the external page of TDLab

Inside the Life Science Trace Detection Laboratory

Laser spectroscopy TDLab

Laser spectroscopy

Our laboratory houses and develops different optical/laser sources. Coupled to advanced absorption spectroscopy techniques, they possess strong capabilities for trace gas detection, including biological, environmental, and medical applications. The infrastructure is equipped for gases like ethylene, methane, nitrogen oxide, carbon dioxide, aldehydes, alcohols, ketones, acids, and many more.

Techniques

  • Laser sources: E.g., Quantum Cascade Lasers (QCLs), Optical Parametric Oscillators (OPOs), Broadband mid-infrared supercontinuum sources, EO-based Dual-Comb Source, Broadband Tunable chip-based lasers
  • Time-Resolved Dual-Comb Spectroscopy (DCS)
  • Spectrometers: E.g., Fourier Transform Spectrometers (FTS) and Grating Spectrometers (GS)

Figure: Typical absorption regions of some important gases (Generated by SpectralCalc).

The GC-IMS in the TDLab

Mass spectrometry

The laboratory possesses various mass spectrometry instruments. Tailored for applications in detecting trace gases for medical, agricultural, and environmental applications, the group specializes in detection of volatile organic compounds (VOCs) such as alcohols, aldehydes, ketones, carboxylic acids, aromatic compounds, nitriles, amines, amides, thiols, and sulphides.

Techniques

  • Selective Reagent Ion/Proton Transfer Reaction – Time-of-Flight – Mass Spectrometry (SRI/PTR-ToF-MS)
  • Proton-Transfer Reaction Mass Spectrometry (PTR-MS)
  • Gas Chromatography – Ion Mobility Spectrometry (GC-IMS)
  • Gas chromatography – Mass Spectrometry (GC-MS)

Photo: The GC-IMS in the TDLab.

Applications

The TDLab uses state-of-the-art laser-based spectroscopy and mass spectrometry for a wide range of gas concentrations (from sub ppb level to ppm and percentages). Most of these methodologies are developed for reliable detection and quantification of volatile compounds in a specific application. Various examples of applications include: Breath analysis, Post-harvest research, Chemical reactions in plasmas, Measuring pollutants and outdoor emissions, Microbiology, Entomology, and Plant physiology.

Projects

The facility is part of the Analytical Chemistry & Chemometrics department. Below is a video of the FLying ultrA-broadband single-shot Infra-Red sensor (FLAIR), a finished project where UAV-mounted sensors were used for large-scale, sensitive air quality monitoring to combat air pollution and its severe health impacts.

Discover current projects

Contact & Access

The Life Science Trace Detection Laboratory is located in the Huygens building, 1st floor, wing 7. For more information or to request access, please get in touch with Simona Cristescu.