Studying pandemic viruses
The SHIELD project will focus on better understanding viruses with high pandemic potential, such as the Lassa virus, Nipah and Hendra viruses, West Nile virus, Zika virus, Dengue virus (responsible for dengue fever), and yellow fever virus. SHIELD's primary objectives are to investigate two critical aspects of these viruses: the dynamics of virus particles, and the glycosylation of virus particles. These research areas are still poorly understood but are crucial for developing effective antiviral therapies. The team will map how viral proteins are glycosylated, which is essential for the virus to attach to and infect host cells. By identifying new binding locations involved in viral attachment and fusion, the researchers aim to discover new leads for therapies, such as inhibitors or antigens that can block the entry of viruses into cells. "We are extremely happy with this grant, as the project has the potential to advance the development of future antiviral drugs and vaccines against these dangerous viruses”, the research team says.
The international consortium of researchers from eight European countries, has been awarded a total of 9 million euros. “The true strength of this large and diverse consortium lies in its extensive multidisciplinary expertise, which is essential for effectively tackling these complex and challenging viruses”, the team emphasizes.
Synthetic Organic Chemistry
All researchers work in the Synthetic Organic Chemistry department, led by Professor Rutjes. The research group is part of the IMM and designs and synthesises biologically relevant small molecules and develops new sustainable synthesis methods. The fundamentally orientated group actively seeks collaborations with business and industry.
Horizon Europe
The Horizon Europe programme, the ninth framework from the European Commission, supports research and innovation across various fields. Their missions are focused on solving global challenges like fighting cancer, adapting to climate change, protecting oceans, promoting greener cities, and ensuring soil and food quality. SHIELD is within the scope of the program's pandemic preparedness mission, aiming to enhance global health security.
