Research projects
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Characterization of therapeutic anti-CXCR4 antibodies
In this project, we characterize therapeutic antibodies against CXCR4, which have been selected from large scFv phage libraries and engineered into complete human(ised) antibodies in collaboration with ModiQuest BV.
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Are glycans crucial determinants of autoantibody reactivity?
In this project, the role of glycosylation in the autoantibody response in MS and IBDs will be explored.
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Dissecting sialoglycan recognition by Siglecs
We dissect this specific binding context of the human Siglec family to unravel their role in the immune system and inflammatory diseases.
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Developing genetic and chemical strategies for glycoprotein engineering
Using precise genome editing tools, we stably delete and insert specific combinations of glycosyltransferases to generate cells that assemble specific glycan structures.
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Probing mucin glycans at the host-microbiome interface
We develop novel mucin-based molecules to investigate how specific bacteria degrade mucins.
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The molecular basis of the accumulation of cytosolic 5’-nucleotidase 1A in inclusion body myositis
In this project we focus on two aspects: the anti-cN1A response in IBM patients and the intracellular accumulation of cN1A.
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Agglutination assay for rheumatoid arthritis biomarkers
The project aims to make early testing more accessible, both for screening at primary care providers and in countries around the world lacking the infrastructure for more advanced tests.