Life Science Trace Detection Laboratory

The Life Science Trace Detection Laboratory or TDLab (part of Analytical Chemistry and Chemometrics) operates a variety of state-of-the-art trace gas detectors that allow real time measurements with detection levels at or below parts per billion volume level. 

The experiments offer high temporal and spatial resolution, so that fast reactions of biological material become directly observable. The laboratory is available to internal and external users.

Inside the Life Science Trace Detection Laboratory

Laser spectroscopy TDLab

Laser spectroscopy

Our laboratory houses and develops different optical/laser sources. Coupled to advanced absorption spectroscopy techniques, they are used for trace gas detection, including biological, environmental, and medical applications. The infrastructure is equipped for gases like ethylene, methane, nitrogen oxide, carbon dioxide, aldehydes, alcohols, ketones, acids, and many more.

Techniques

  • Laser sources: Quantum Cascade Lasers (QCLs), Optical Parametric Oscillators (OPOs), Broadband mid-infrared supercontinuum sources, EO-based Dual-Comb Source, Broadband Tunable chip-based lasers
  • Time-Resolved Dual-Comb Spectroscopy (DCS)
  • Fourier Transform Spectrometer (FTS)
  • Grating Spectrometer (GS)

Figure: Typical absorption regions of some important gases (Generated by SpectralCalc).

The GC-IMS in the TDLab

Mass spectroscopy

Our laboratory houses and develops different optical/laser sources. Coupled to advanced absorption spectroscopy techniques, they are used for trace gas detection, including biological, environmental, and medical applications. The infrastructure is equipped for gases like ethylene, methane, nitrogen oxide, carbon dioxide, aldehydes, alcohols, ketones, acids, and many more.

Techniques

  • Selective Reagent Ion/Proton Transfer Reaction – Time-of-Flight – Mass Spectrometry (SRI/PTR-ToF-MS)
  • Proton-Transfer Reaction Mass Spectrometry (PTR-MS)
  • Gas Chromatography – Ion Mobility Spectrometry (GC-IMS)
  • Gas chromatography – mass spectrometry (GC-MS)

Photo: The GC-IMS in the TDLab.

Applications

In the facility you can use-of-the-art laser-based spectroscopy and mass spectrometry for a wide range of gas concentrations (from sub ppb level to ppm and percentages). Most of these methodologies are developed for reliable detection and quantification of volatile compounds in a specific application. Various examples of applications include: Breath analysis, Post-harvest research, Chemical reactions in plasmas, Measuring pollutants and outdoor emissions, Microbiology, Entomology, and Plant physiology.

Projects

The facility is used in many projects of the Analytical Chemistry & Chemometrics department. Below is for instance a video of the FLying ultrA-broadband single-shot Infra-Red sensor (FLAIR), a finished project where UAV-mounted sensors were used for large-scale, sensitive air quality monitoring to combat air pollution and its severe health impacts.

Discover current projects

Contact & Access

The Life Science Trace Detection Laboratory is available to internal and external users. The facility is located in the Huygens building, 1st floor, wing 7. 

For more information or to request access, please get in touch with Simona Cristescu.