Postdoctoral Researcher for Molecular Mechanisms of Motor Neurodegeneration

Employment
1.0 FTE
Gross monthly salary
€ 2,960 - € 4,670
Required background
PhD
Organizational unit
Faculty of Science
Application deadline
Are you a scientist with a PhD degree or close to obtaining a PhD degree in neurobiology or a related field, and interested in a scientific career? Are you passionate about science and a critical and creative thinker? Are you interested in exploring the molecular mechanisms underlying motor neurodegenerative disease and perform cutting-edge biomedical research? Then you have a part to play as a postdoc! 

We are recruiting an ERC-funded postdoctoral researcher who will work independently on mouse genetics projects. One project will investigate the contribution of the skeletal muscle to motor neuron and neuromuscular junction degeneration in ALS associated with mutations in TDP-43, using advanced mouse genetic approaches (conditional transgenic models) in combination with behavioural, electrophysiological, histochemical, imaging and molecular approaches. The latter include single-nucleus RNA sequencing and single molecule FISH, as well as viral gene transfer approaches. In addition, you will have the opportunity to contribute to other ongoing projects at the lab, for example studying the role of the skeletal muscle in ALS-FUS and/or the molecular pathogenesis of CMT associated with mutations in tyrosyl-tRNA synthetase, both projects following up on our recent work (Picchiarelli et al, Nat Neurosci, 2019; Zuko, Mallik et al, Science, 2021). You will collaborate with and supervise Master's students, and in the longer run possibly also PhD candidates. You will get some exposure to teaching in Master's courses. In the long run, the development of an independent research project that can be transferred to a future position is possible and highly encouraged.

Profile

  • You are a highly motivated, passionate, critical and creative individual with a strong publication record. 
  • You are team-oriented, open to provide and receive feedback to/from lab mates, and keen to engage in scientific discussions.
  • You hold a PhD in neurobiology or a related field, and are interested in a scientific career.
  • You have previous experience with mouse genetics and molecular biology.
  • We are a dynamic international lab, so a good command of English is essential.

We are

Within the Department of Molecular Neurobiology, the Storkebaum lab combines Drosophila and mouse genetics to unravel molecular mechanisms underlying motor neurodegenerative disorders. We currently focus on Charcot-Marie-Tooth (CMT) peripheral neuropathy associated with mutations in tRNA synthetases and on amyotrophic lateral sclerosis (ALS) associated with mutations in FUS. More broadly, we are interested in the role of mRNA translation defects in axonal degeneration. We use a broad spectrum of methods and techniques including a recently developed method for in vivo labelling of newly synthesised proteins, several high-end imaging techniques (confocal and super-resolution microscopy), single-molecule FISH, next-generation sequencing, mouse and Drosophila behavioural analysis, electromyography, mouse stereotaxic injections and surgery for implantation of pumps for chronic brain infusion, histology, immunohistochemistry, molecular biology and biochemistry. Our team currently consists of two postdoctoral researchers, four PhD candidates and one technical assistant. In addition, we have strong international collaborations with scientists working on RNA biology and genetics. We attracted substantial external funding, including an ERC Consolidator grant, two JPND grants, and grants from the Radala Foundation for ALS Research, the Muscular Dystrophy Association (MDA), AFM, ARSLA, the Dutch ALS Association, the 'Prinses Beatrix Spierfonds' and the Dutch Research Council (NWO). We have published several papers in high-impact journals, including Science, Nature Neuroscience, Journal of Cell Biology, Nature Communications, Acta Neuropathologica, EMBO Journal and Plos Genetics.

Radboud University

We want to get the best out of science, others and ourselves. Why? Because this is what the world around us desperately needs. Leading research and education make an indispensable contribution to a healthy, free world with equal opportunities for all. This is what unites the more than 24,000 students and 5,600 employees at Radboud University. And this requires even more talent, collaboration and lifelong learning. You have a part to play!

We offer

  • It concerns an employment for 1.0 FTE. 
  • The gross monthly salary amounts to a minimum of €2,960 and a maximum of €4,670 based on a 38-hour working week, depending on previous education and number of years of relevant work experience (salary scale 10).
  • You will receive 8% holiday allowance and 8.3% end-of-year bonus.
  • The contract is for an initial period of 2 years with the option to extend for a further 2 years.
  • You will be able to use our Dual Career and Family Care Services. Our Dual Career and Family Care Officer can assist you with family-related support, help your partner or spouse prepare for the local labour market, provide customized support in their search for employment and help your family settle in Nijmegen.
  • Working for us means getting extra days off. In case of full-time employment, you can choose between 29 or 41 days of annual leave instead of the legally allotted 20.
  • The vibrant international environment of the Donders Institute, which has a long tradition in neuroscience and offers a personal career development plan along with lecture series featuring top-notch speakers as well as several internal seminar series.
  • You will be able to attend a Dutch language course free of charge.

Additional employment conditions

Work and science require good employment practices. This is reflected in Radboud University's primary and secondary employment conditions. You can make arrangements for the best possible work-life balance with flexible working hours, various leave arrangements and working from home. You are also able to compose part of your employment conditions yourself, for example, exchange income for extra leave days and receive a reimbursement for your sports subscription. And of course, we offer a good pension plan. You are given plenty of room and responsibility to develop your talents and realise your ambitions. Therefore, we provide various training and development schemes.

Would you like more information?

For questions about the position, please contact Prof. Erik Storkebaum, Group leader and head of the Department of Molecular Neurobiology at erik.storkebaum [at] donders.ru.nl.

Practical information and applying

You can apply until 12 October 2022, exclusively using the button below. Kindly address your application to Prof. Erik Storkebaum. Please fill in the application form and attach the following documents:
  • A letter of motivation.
  • Your CV including the contact details of at least two references.
 
The first round of interviews will take place in the last week of October. You would preferably begin employment on 1 January 2023.

We can imagine you're curious about our application procedure. It offers a rough outline of what you can expect during the application process, how we handle your personal data and how we deal with internal and external candidates.
Apply now Application deadline

We would like to recruit our new colleague ourselves. Acquisition in response to this vacancy will not be appreciated.

Prof. Storkebaum, E.J.M. (Erik)

Group leader and head of the Department of Molecular Neurobiology

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