T.T.Y. Le

Yen Le

Dr T.T.Y. Le (Yen)

Current working place/position:
Research fellow of the Alexander von Humboldt foundation
Department of Aquatic Ecology
Faculty of Biology
University of Duisburg-Essen
Universitätsstrasse 5
D-45141 Essen Germany
Room: S05T03B23
Tel: +49 (0)201 183 4695
Email: yen.le@uni-due.de; yenle@science.ru.nl
http://www.uni-due.de/aquatische_oekologie/mitarbeiter/gaeste.shtml http://www.ru.nl/environmentalscience/staff/individual-staff/le/

Current project:
Description: Fish are affected by both chemical exposure and parasite infection. Moreover, metals may affect parasitism by influencing the immune system of the host while parasites may impact metal accumulation in the host because parasites themselves can take up metals. In many cases, it has been reported than metal concentrations in parasites were higher than the concentrations in the host. Another effect of parasites is on a detoxification mechanism, i.e., the induction of metallothionein, which has been considered as a potential biomarker of metal bioavailability. Therefore, it is important to study metal accumulation in parasite-host systems. The partitioning of chemicals between parasites and their hosts is usually expressed by a ratio between concentrations in parasites and their hosts. We aimed to estimate metal accumulation in parasite-host systems from a more mechanistic respect. The project is funded by the Alexander von Humboldt foundation and carried out at the university of Duisburg-Essen, Germany.
Internships: available

Here you can find citations of my articles.


General: Specification and modelling of chemical-organism interactions

Specific: Bioaccumulation and subcellular distribution in organisms and their relationships to toxicity, mechanistic modelling, human and ecological risk assessment

Disciplines: Ecological and human toxicology, environmental chemistry, ecotoxicological modelling


2000-2003: Chemistry-specialised high school, Hanoi University of Science, Vietnam National University Hanoi, Vietnam

2003-2007: BSc in Environmental Science, Hanoi University of Science, Vietnam National University Hanoi, Vietnam

2009-2011: MSc in Environmental Science, Radboud University Nijmegen, the Netherlands

2011-2012: PhD in Environmental Science, Radboud University Nijmegen and National Institute for Public Health and the Environment (RIVM), the Netherlands

Scholarship / Fellowship

  • Huygens Scholarship for 2-year Master programme in Environmental Science(2009-2011)
  • Alexander von Humboldt Stiftung/Foundation: 2-year fellowship for postdoctoral researchers, November 2012


  • 2010-2012: Modelling bioaccumulation and toxicity of metal mixtures
  • 2013-2014 (current): Improving the exposure assessment through vegetable consumption by developing a mechanistic model estimating metal bioaccumulation in vegetables. The project is funded by Ministry of Infrastructure and the Environment, the Netherlands

    : Radboud University Nijmegen, National Institute for Public Health and the Environment, Wagenigen University and Research Centre

    Abstract: Determining concentrations of metals accumulated in vegetables is one of the most important stages in the CSOIL exposure model for human health risk assessment of soil contamination. In assessment of human exposure through vegetable consumption in general and in the CSOIL model in particular, approaches applied for the determination of metal accumulation in vegetables are usually empirical (‘black box'), i.e., based on experimental data for case-by-case validation. The extrapolation and application of these approaches for site-specific risk assessment are limited. The proposed research aims at developing and validating a mechanistic model, including physiological, chemical, and biological processes that are simulated in relation to chemical properties of metals, vegetable-specific physiological characteristics, and physicochemical conditions of the environment. This model provides a more reliable estimate of accumulation in vegetables of a number of metals and environmental conditions without need for site-specific calibration and subsequently more accurate human health risk assessment. Moreover, the model offers the possibility to assess the exposure though vegetable consumption for metals for which significant empirical relations are lacking. This model might therefore improve the range of application in Sanscrit and the reliability of the determination of the remediation urgency (detailed site-specific exposure assessment with regard to Tier 2 of the Sanscrit computer package).

Internships: Available

Next project: Development and validation of a mechanistic model simulating metal uptake of the parasite Paratenuisentis ambiguus from its host, the European eel Anguilla anguilla (At University of Duisburg Essen, Germany)


PhD thesis

T.T. Yen Le. 2012. Modelling bioaccumulation and toxicity of metal mixtures. ISBN: 978-94-91066-06-1. http://repository.ubn.ru.nl/bitstream/2066/100831/1/100831.pdf

International journals


  • Le TTY, F Swartjes, P Römkens, JE Groenenberg, P Wang, S Lofts & AJ Hendriks, 2014. Modelling metal accumulation using humic acid as a surrogate for plant roots. Chemosphere (in press). Online: 4 December 2014doi:10.1016/j.chemosphere.2014.11.003
  • Le TTY, P Wang, MG Vijver, TB Kinraide, AJ Hendriks & WJGM Peijnenburg, 2014. Delineating ion-ion interactions by electrostatic modelling for predicting rhizotoxicity of metal mixtures to lettuce Lactuca sativa. Environmental Toxicology and Chemistry 33: 1988-1995. doi: 10.1002/etc.2643.
  • Le TTY, L Rijsdijk, B Sures & AJ Hendriks, 2014. Accumulation of persistent organic pollutants in parasites. Chemosphere 108: 145-151. doi: 10.1016/j.chemosphere.2014
  • Le TTY & AJ Hendriks, 2014. Uncertainties associated with lacking data for predictions of solid-solution partitioning of metals in soil. Science of the Total Environment 490: 44-49. doi:10.1016/j.scitotenv.2014.04.124.


  • Le TTY & AJ Hendriks, 2013. Relationships between absorption efficiency of elements in mammals and chemical properties. Critical Reviews in Toxicology 43(9): 800-809. doi:10.3109/10408444.2013.813906
  • Le TTY & WJGM Peijnenburg, 2013. Modelling toxicity of mixtures of perfluorooctanoic acid and triazoles (triadimefon and paclobutrazol) to the benthic cladoceran Chydorus sphaericus. Environmental Science and Technology 47(12): 6621-6629. doi: 10.1021/es4001104
  • Le TTY, MG Vijver, TB Kinraide, WJGM Peijnenburg & AJ Hendriks, 2013. Modelling metal-metal interactions and metal toxicity to lettuce Lactuca sativa following mixture exposure (Cu2+-Zn2+ and Cu2+-Ag+). Environmental Pollution 176: 185-192. doi: 10.1016/j.envpol.2013.01.017
  • Le TTY, MG Vijver, AJ Hendriks & WJGM Peijnenburg, 2013. Modelling toxicity of binary metal mixtures (Cu2+-Ag+, Cu2+-Zn2+) to lettuce Lactuca sativa, with Biotic Ligand Model. Environmental Toxicoly and Chemistry 32(1): 137-143. doi: 10.1002/etc.2039


  • Le TTY, WJGM Peijnenburg , AJ Hendriks & MG Vijver, 2012. Predicting effects of cations on copper toxicity to lettuce (Lactuca sativa) by the biotic ligand model. Environmental Toxicology and Chemistry 31(2): 355-359. doi: 10.1002/etc.736


  • Le TTY, RSEW Leuven & AJ Hendriks, 2011. Modelling metal bioaccumulation in the invasive mussels Dreissena polymorpha and Dreissena bugensis in the rivers Rhine and Meuse. Environmental Toxicology and Chemistry 30(12): 2825-2830. doi: 10.1002/etc.685

National journals

  • Nguyen KBT, Le TTY. 2007. Assessing the safety of the bioproduct Lipomycin M. to soil ecosystem in the hill soil Me Linh-Vinh Phuc. Youth Union's Scientific Journal, 81-87.
  • Nguyen TH, Tran TH, Nguyen TTN, Do TCV, Le TTY. 2007. Preliminary study on removal of some heavy metals (Cu2+, Pb2+, Zn2+) in water by biosorption using Saccharomyces cerevisiae. Journal of Science 23, 99-106.


  • Le, T.T.Y. & A.J. Hendriks, 2014. Improving the exposure assessment through vegetable consumption by developing a mechanistic model estimating metal bioaccumulation in vegetables. Reports Environmental Science no 471. Radboud University, Nijmegen. 158 p. (PDF (pdf, 2,8 MB))

Conference proceedings

  • Nguyen TH, Pham VQ, Le TTY. 2008. Study on Cu(II) and As(III) biosorption capacity of Pseudomonas aeruginosa. Proceedings of 2008 International Conference on Environmental Quality Concern, Control and Conservation. 23-23 May, 2008. pp 361-370.

Last update: 11th of December 2014