User station 9: Quadrupole ion trap MS for IR ion spectroscopy

This instrument is built upon a commercial Bruker Amazon Speed ETD ion trap mass spectrometer, which has been modified to enable optical access to the ions stored in the trap.

The instrument can be used with an analytical electrospray ionization source or alternatively an atmospheric pressure chemical ionization source. A key advantage of this experiment is its high sensitivity; typical sample concentrations are in the 10^-5 – 10^-8 M range. MS and IR experiments can be coupled with liquid chromatography (Bruker Elute) to enable the measurement of low abundance components in complex mixtures such as body fluid samples. The instrument has many MSⁿ options, including multiple stages of CID and (single stage) ETD. Interfacing of the electronics and software of the MS with that of FELIX to enable automated IR spectra collection has been installed.

More information: Analytical Ion Spectroscopy, Ion Chemistry, Astrochemistry.

• Infrared ion spectroscopy in a modified quadrupole ion trap mass spectrometer at the FELIX free electron laser laboratory.
  J. Martens, G. Berden, C.R. Gebhardt, and J. Oomens
  Review of Scientific Instruments 88 (2016) 6126–6129.
  © 2016 American Institute of Physics. Review of Scientific Instruments (2016)
  
  
• Molecular identification in metabolomics using infrared ion spectroscopy.
  J. Martens, G. Berden, R.E. van Outersterp, L.A.J. Kluijtmans, U.F. Engelke, C.D.M. van Karnebeek, R.A. Wevers, and J. Oomens
  Scientific Reports 7 (2017) 3363.
  © 2017 Nature Group. Scientific Reports (2017)
  
  
• Unraveling the unknown areas of the human metabolome: the role of infrared ion spectroscopy.
  J. Martens, G. Berden, H. Bentlage, K.L. Coene, U.F. Engelke, D. Wishart, M. van Scherpenzeel, L.A.J. Kluijtmans, U.F. Engelke, C.D.M. van Karnebeek, R.A. Wevers, and J. Oomens
  Journal of Inherited Metabolic Disease 41 (2018) 367–377.
  © 2018 Springer. Journal of Inherited Metabolic Disease (2018)
  
  
• An automatic variable laser attenuator for IRMPD spectroscopy and analysis of power-dependence in fragmentation spectra.
  G. Berden, M. Derksen, K.J. Houthuijs, J. Martens, and J. Oomens
  International Journal of Mass Spectrometry 443 (2019) 1–8.
  © 2019 Elsevier. International Journal of Mass Spectrometry (2019)
  
  
• Structural identification of electron transfer dissociation products in mass spectrometry using infrared ion spectroscopy.
  J. Martens, J. Grzetic, G. Berden, and J. Oomens
  Nature Communications 7 (2016) 11754.
  © 2016 Springer Nature. Nature Communications (2016)