Review: Gas-Phase Infrared Spectroscopy of Neutral Peptides: Insights from the Far-IR and THz Domain
FELIX researchers Sjors Bakels and Anouk Rijs have published, together with Marie-Pierre Gaigeot (Université d’Evry), a review paper on the state-of-the-art of infrared action spectroscopy of peptides in the far-IR and THz regime. Their review is part of a special issue of Chemical Reviews from the American Chemistry Society on the Bond Specific Spectroscopy of Peptides and Proteins.
Gas-phase, double resonance infrared (IR) spectroscopy has proven to be an excellent approach to obtain structural information on peptides, ranging from single amino acids to large peptides and peptide clusters. The state-of-the-art of this technique in the far-IR and THz regime (which can be generated at FELIX) is discussed, with the aim to underline how the synergy between far-IR spectroscopy and theory can provide an unprecedented picture of the structure of neutral biomolecules in the gas phase. With a far-IR map the authors give insight into the origin of far-IR localized and delocalized motions present in peptides and where they can be found in the electromagnetic spectrum.
Gas-Phase Infrared Spectroscopy of Neutral Peptides: Insights from the Far-IR and THz Domain. Sjors Bakels, Marie-Pierre Gaigeot and Anouk M. Rijs, Chemical Reviews 120, 3233-3260 (2020)