News
Research using FELIX for the discovery of novel biomarkers in pyridoxine-dependent epilepsy described in new publication in Analytical Chemistry.
12 November 2021
Novel biomarkers for pyridoxine-dependent epilepsy identified using untargeted metabolomics and infrared ion spectroscopy
7 July 2021
HFML-FELIX research featured in "Medisch Contact"
7 July 2021
Sir Harry Kroto, astronomer and Nobel Laureate for the discovery of C60, predicted 30 years ago that protonated fullerenes are among the most abundant fullerene derivatives in interstellar environments. Julianna Palotás and her coworkers at FELIX have now recorded the first IR spectrum of C70H+. This spectral signature may guide astronomers in the search for these species, to corroborate Kroto’s predictions.
23 March 2021
Scientists identified isomeric designer drugs using a single infrared laser for two-color infrared IR2MS3 experiments.This greatly reduces the experimental complexity of two-color IR2MS3 and enhances its application in fields employing analytical MS.
22 January 2021
Several companies use our facilities for their research & development. They buy experimental time and expertise. For example, Janssen Research & Development (a division of Janssen Pharmaceutical). Read the interview with Head Analytical Sciences Filip Cuyckens.
10 December 2020
In the latest issue of the NVtN you can find a contribution of Jos Oomens,Julianna Palotás, Jonathan Martens and Giel Berden about the IR spectrum of protonated buckminsterfullerene, C60H+ . This is based on their publication in Nature Astronomy last November.
4 September 2020
On the latest issue of C2W FELIX Laboratory is on the cover. Inside an article on Terahertz-spectroscopy. Anouk Rijs is interviewed on the unique combination of THz and IR spectroscopy and mass spectrometry her group uses
9 June 2020
The global synthetic drug market has been rapidly expanding to include many novel psychoactive substances (NPS). These designer drugs have chemical structures closely related to ‘traditional’ drugs. Due to the minor variations in molecular structure these NPS induce similar psychoactive effects, but change their legal status and potentially cause severe health effects. Common approaches for isomeric drug identifications are limited. Using infrared ion spectroscopy at FELIX Laboratory, researchers were able to identify NPS even with limited (or none) availability of reference samples, sample impurities or mixtures. This is highly beneficial for the forensic field.
5 June 2020
Controlling the chemical linkage of sugars (glycosylation reaction) is a great challenge in the organic chemistry. The chemical glycosylation often results in a mixture of products due to the creation of a new chiral centre. The structure of the reactive intermediates formed during the glycosylation reaction have been a mystery for a long time. Until now. A team of researchers from Leiden University, HFML-FELIX and the Institute for Molecules and Materials (IMM) have discovered how distal acyl groups can play a critical role in determining the outcome of glycosylation reactions. The results have been published in Nature Communications
29 May 2020