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IMM colloquium April 2019: "high-dimensional single cell analysis of anti-tumor immune responses" (Lecture)

Tuesday 23 April 2019Add to my calendar
from 16:00
dr. Enrico Lugli (Humanitas Research Hospital, Milano, Italy)

Enrico LugliIn response to immune activation, naive CD8+ T cells generate a large number of effector cells capable to migrating to peripheral tissues and kill infected cells. When antigen is cleared, a small population of antigen-specific T cells survives and differentiates into a pool of long-lived memory T cells that is highly diverse at the transcriptional, metabolic, epigenetic and functional levels. Single cell technologies are revolutionizing biology, and are opening new insights on how biological processes are regulated. We recently extended flow cytometry capability to measure up to 30-parameters on single cells and are combining it with single cell RNA sequencing to investigate T cell differentiation in physiology and pathology. In this talk, I will show the vast diversity of T cell responses in human tumors and how different subpopulations shape anti-tumor immunity and disease progression.

dr. Jeroen Jansen