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IMM colloquium February 26 by Tom de Greef: "Development of a DNA-based Molecular Computer" (Lecture)

Date
Tuesday 26 February 2019Add to my calendar
Time
from 16:00
Location
HG00.307
Speaker
prof. Tom de Greef (Biophysical Chemistry)
Preceding lecture
Zhongfa Sun (Mol. and Laser Physics): "Scattering of Identical Molecules: Imaging CO+CO rotational energy transfer"
Description

Tom de GreefThe next great change in information technology will come from mimicking the strategies by which biological organisms process information. Here we outline the design of a molecular computer based on programmable DNA strand-displacement reactions. We reveal how the speed, scalability and stability of DNA-based molecular circuits can be improved by compartmentalization strategies such as tethering of DNA gates to surfaces or encapsulation in semi-permeable capsules. In addition, we discuss strategies to interface DNA strand displacement circuits with non-nucleic based inputs. Autonomous biomolecular systems with sophisticated signal integration, processing and actuation properties present a unique platform for applications in synthetic biology, biomedicine and molecular diagnostics.