Theme 2 colloquium by prof. Elias Vlieg: 'Deracemization of everything? ' (Lecture)
- Tuesday 10 March 2020Add to my calendar
- from 16:00
prof. Elias Vlieg (Solid State Chemistry)
Understanding how single-handedness of biological molecules came about has been of interest since Pasteur first separated mirror-image crystals of tartaric acid. It is also highly relevant, since for pharmaceutical applications it is often necessary to produce a chirally pure product, i.e. containing only one of the two possible enantiomers. There are several chiral purification or resolution methods. Here crystallization routes will be discussed that can convert a racemic mixture to 100% chiral purity, with a focus on so-called Viedma ripening and temperature cycling. Our current understanding and our efforts to extend their range of applicability will be discussed.
Peter Korevaar & Evan Spruijt