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Theme 2 colloquium: 'Are Two better than One? The exploration of ‘Expanded Pincer’ Ligands in Small Molecule Activation and Homogeneous Catalysis' (Lecture)

Tuesday 12 July 2022Add to my calendar
from 16:00
dr. Danny Broere (Utrecht University)

Danny BroereVarious metalloenzyme active sites feature complex architectures that enable multiple metals and ligands to work together to facilitate bond activation processes that are essential to enzyme function.1 Drawing inspiration from nature, various research groups have developed synthetic systems where metals and ligands cooperatively activate chemical bonds.2 Another avenue in cooperative bond activation involves complexes wherein multiple metal centers are positioned in close proximity and work together to make/break chemical bonds.3 However, whereas nature often uses both strategies simultaneously, synthetic chemists have some catching up to do. This lecture will revolve around the question: “Are Two Better than One?”. In search for an answer, I will highlight how nature exploits multimetallic cofactors to catalyze challenging chemical transformations. Subsequently, I will take a deep dive into the synthetic systems that we have developed in my group.4 These so called ‘expanded pincer’ ligands systems can bind two individual metal atoms in a way that they are located within each other’s van der Waals radii. Finally, I will show how this unique motif enables distinct stoichiometric and catalytic reactivity from their mononuclear counterparts.

[1] a) Armstrong, F.A.; Ragsdale, S.W. Chem. Rev. 2014, 114, 4149; b) Lubitz, W.; Ogata, H.; Rüdiger, O.; Reijerse, E.; Chem. Rev. 2014, 114, 4081; d) Wodrich, M. D.; Hu, X. Nat. Rev. Chem. 2017, 2, 0099.
[2] a) Alig, L.; Fritz, M.; Schneider, S. Chem. Rev. 2019, 119, 2681; b) Khusnutdinova, J. R.; Milstein, D. Angew. Chem. Int. Ed. 2015, 54, 12236.
[3] Iglesias, M.; Sola, E.; Oro, L. A. Homo - and Heterobimetallic Complexes in Catalysis: Cooperative Catalysis; Kalck, P., Ed.; Springer International Publishing: Cham, Switzerland, 2016.
[4] www.broerelab.com/publications

This lecture is part of the IMM Theme 2 – Chemistry of Complex Systems – colloquium series, in which researchers from IMM Theme 2 as well as high-profile researchers from outside Radboud University present work that is of interest to scientists across chemistry, physics and biology. We aim for diversity in the selection of topics and researchers. These lectures take place on the second Tuesday of every month and are open to everyone in who is interested.

Peter Korevaar, Evan Spruijt, Willem Velema