Inaugural Speech prof. Jos Oomens: "Spectroscopie in actie: van astrochemie tot biomarker discovery" (Lecture)
- Thursday 29 November 2018Add to my calendar
- from 15:45
Academiezaal Aula, Comeniuslaan 2
prof. Jos Oomens (Molecular Structure and Dynamics)
Elucidation of molecular structures provides answers to many fundamental and applied questions in the chemical, biological and medical sciences. Both infrared spectroscopy and mass spectrometry are important pillars on which analytical chemistry rests. The combination, or rather integration, of these techniques leads to synergistic advantages: the structure-resolution of IR spectra integrated with the sensitivity and selectivity of MS. A laser source that can be tuned in wavelength is a prerequisite for this and the FELIX infrared laser offers unique possibilities.
Oomens shows how this new method has evolved from purely fundamental research, for example in astrochemistry and ion chemistry, to a technique that is increasingly used in the identification of unknown unknowns in complex mixtures. The elucidation of the molecular structure of biomarkers for congenital metabolic diseases, occurring in minuscule amounts in patient blood or urine samples, is one of the first tangible results.
Jos Oomens (1968) obtained his doctorate at Radboud University in 1996 on a topic in the field of molecular spectroscopy. From 1999 to 2013, he was affiliated with the FOM Institute for Plasma Physics Rijnhuizen in Nieuwegein, where he developed a method in which the FELIX free-electron laser is used to record infrared spectra of gaseous molecular ions with a mass spectrometer and implemented this method into a large number of ionised systems. In 2009, he was appointed adjunct professor of Action Spectroscopy at the University of Amsterdam. In 2013, he and the FELIX laboratory moved to Radboud University where he was appointed Professor of Molecular Spectroscopy and Dynamics. He developed methods for using infrared ion spectroscopy to identify molecular structures in complex mixtures and applied them, inter alia, in the identification of metabolites in a collaboration with Prof. Ron Wevers of Radboud university medical center.