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Summer School on Chiral Crystallization, Resolution & Deracemization (Conference)

Date
Monday 3 July 2017 until Thursday 6 July 2017Add to my calendar
Location
HG00.068
Description


figuur summer school STC july2017The goal of this summer school is to outline the basics of chirality and chiral purification in the context of crystallisation. In 1848 Louis Pasteur discovered that biological molecules can be chiral, i.e., occur in both a left‐handed and a right‐handed form. Such molecules are each other’s (non‐superimposable) mirror image, but identical otherwise. In a normal chemical synthesis the two enantiomers will be produced in equal amounts. Life on earth, however, is found to be predominantly homochiral, with only one type of handedness present of a specific biomolecule. On the one hand this raises the fundamental question how this single‐handedness occurred. On the other hand this has practical consequences since the human body can respond very differently to the two enantiomers and thus for pharmaceutical applications it is often necessary to produce a chirally pure product.

This summer school will teach the participants the current state of the art in different routes to produce chirally pure material. The focus is on methods involving crystallisation, and thus the school starts with the fundamentals of crystal growth and the crystallography of chiral compounds. Subsequently the most important chiral purification methods will be presented.

More information and program can be found here.