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Seminar: 'Substrate induced catalyst formation under non-equilibrium conditions' (Lecture)

Date
Wednesday 13 July 2022Add to my calendar
Time
from 15:30
Location
HG.00.062
Speaker
Dr. Dibyendu Das (Department of Chemical Sciences, IISER Kolkata, India)
Description

There remain critical gaps in our understanding of the emergence of functional biopolymers in the origins of Earth’s biosphere. For instance, extant proteins, evolved over millions of years, carry out an impressive array of responsibilities, from catalysis and molecular recognition to motility and compartmentalization. One of the major goals of our lab is to investigate the possible origins of advanced enzymatic functions from folds of short peptide based paracrystalline phases. Further, we are excited about understanding the non-equilibrium structures of living systems.1-6 I will show our recent discoveries of simple chemical systems that can be substrate-driven to access higher energy self-assembled states, just as seen in natural microtubules. Further, I will attempt to sketch our aims of developing self-assembled autonomous materials that can show temporal control of functions.5,7-10

References and Notes:

  1. P. Afrose, C. Mahato, P. Sharma, L. Roy, and D. Das*. J. Am. Chem. Soc. 2022, (Just Accepted)
  2. Pal, A. Reja, S. Bal, B. Tikader and D. Das*  Angew. Chem. Int. Ed. 2022, (Just Accepted)
  3. Chatterjee, C. Mahato and D.Das* Angew. Chem. Int. Ed. 2021, 60, 204-209
  4. Sarkhel, A. Chatterjee and D. Das*. J. Am. Chem. Soc. 2020 142 4098-4103
  5. Reja,  S.P. Afrose, D. Das*. Angew. Chem. Int. Ed. 2020 59 4329-4334
  6. Bal, C. Ghosh, T. Ghosh, R. Vijayaraghavan and D. Das*. Angew. Chem. Int. Ed. 2020, 59, 13506
  7. P.Afrose, S. Bal, A. Chatterjee, K. Das, D. Das* Angew. Chem. Int. Ed. 2019 58 15783-1578
  8. Ahmed, A. Chatterjee, K. Das and D.Das* Chemical Science 2019 10 7574-7578
  9. Bal, K. Das, S. Ahmed and D.Das*  Angew. Chem. Int. Ed. 2019 58 244
  10. S. Azevedo, S. L. Perry, P. A. Korevaar, D. Das. Nature Chemistry 2020, 12, 793-794
Contact
dr. Peter Korevaar