Peer-reviewed publications

2023

Synthetic fibrous hydrogels as a platform to decipher cell-matrix mechanical interactions
H. Yuan, K. Liu, M. Cóndor, J. Barrasa-Fano, B. Louis, J. Vandaele, P. De Almeida, Q. Coucke, W. Chen, E. Oosterwijk, C. Xing, H. Van Oosterwyck, P.H.J. Kouwer, S. Rocha
Proc. Natl. Acad. Sci. U. S. A. 120, e2216934120 (2023). [DOI: 10.1073/pnas.2216934120]

The effect of growth factors on vaginal wound healing: a systematic review and meta-analysis
M.J.J. Van Velthoven, A.N. Gudde, F. Struijs, E. Oosterwijk, J.P. Roovers, Z. Guler, C.R. Hooijmans, P.H.J. Kouwer
Tissue Eng. B Rev. 29, 429-440 (2023). [DOI: 10.1089/ten.TEB.2022.0225]

Potential of Estradiol-Functionalized Polyisocyanide Hydrogels for Stimulating Tissue Regeneration of the Pelvic Floor
M.J.J. Van Velthoven, A.N. Gudde, H. Enting, R. Hammink, J.-P. Roovers, Z. Guler, E. Oosterwijk, P.H.J. Kouwer
Adv. Therap. 6, 2300199 (2023). [DOI: https://doi.org/10.1002/adtp.202300199]

Growth Factor Immobilization to Synthetic Hydrogels: Bioactive bfgf-functionalized Polyisocyanide Hydrogels
M.J.J. Van Velthoven, A.N. Gudde, E. Arendsen, J.-P. Roovers, Z. Guler, E. Oosterwijk, P.H.J. Kouwer
Adv. Healthcare Mater. 12, 2301109 (2023). [DOI: https://doi.org/10.1002/adhm.202301109]

A Novel In Vitro Disease Model for Systemic Sclerosis Using Polyisocyanide Hydrogels
J. Kumari, T. Wubs, A.P.M. Van Caam, D.N. Dorst, F.a.D.T.G. Wagener, P.H.J. Kouwer
Adv. Therap. 6, 2200180 (2023). [DOI: 10.1002/adtp.202200180]

Vaginal Fibroblast Behavior as a Function of Stiffness Changes in a Polyisocyanide Hydrogel for Prolapse Repair
A.N. Gudde, M.J.J. Van Velthoven, B. Türkel, P.H.J. Kouwer, J.-P.W.R. Roovers, Z. Guler
ACS Appl. Bio Mater. (2023). [DOI: 10.1021/acsabm.3c00433]

Injectable polyisocyanide hydrogel as healing supplement for connective tissue regeneration in an abdominal wound model
A.N. Gudde, M.J.J. Van Velthoven, P.H.J. Kouwer, J.-P.W.R. Roovers, Z. Guler
Biomaterials 302, 122337 (2023). [DOI: 10.1016/j.biomaterials.2023.122337]

2022

The living interface between synthetic biology and biomaterial design
A.P. Liu, E.A. Appel, P.D. Ashby, B.M. Baker, E. Franco, L. Gu, K. Haynes, N.S. Joshi, A.M. Kloxin, P.H.J. Kouwer, J. Mittal, L. Morsut, V. Noireaux, S. Parekh, R. Schulman, S.K.Y. Tang, M.T. Valentine, S.L. Vega, W. Weber, N. Stephanopoulos, O. Chaudhuri
Nat. Mater. 21, 390-397 (2022). [DOI: 10.1038/s41563-022-01231-3]

Toward Tissue-Like Material Properties: Inducing In Situ Adaptive Behavior in Fibrous Hydrogels
W. Chen, J. Kumari, H. Yuan, F. Yang, P.H.J. Kouwer
Adv. Mater. 34, 2202057 (2022). [DOI: https://doi.org/10.1002/adma.202202057]

A Novel In Vitro Disease Model for Systemic Sclerosis Using Polyisocyanide Hydrogels
J. Kumari, T. Wubs, A.P.M. Van Caam, D.N. Dorst, F.A.D.T.G. Wagener, P.H.J. Kouwer
Adv. Therap. 5, 2200180 (2022). [DOI: https://doi.org/10.1002/adtp.202200180]

Novel Synthetic Polymer-Based 3D Contraction Assay: A Versatile Preclinical Research Platform for Fibrosis
J. Kumari, F.A.D.T.G. Wagener, P.H.J. Kouwer
ACS Appl. Mater. Interfaces 14, 19212-19225 (2022). [DOI: 10.1021/acsami.2c02549]

Polyisocyanides as a substrate to trigger vaginal fibroblast functioning in an in vitro model for prolapse repair
A.N. Gudde, M.J.J. Van Velthoven, J.-P.W.R. Roovers, P.H.J. Kouwer, Z. Guler
Biomater. Adv. 141, 213104 (2022). [DOI: https://doi.org/10.1016/j.bioadv.2022.213104]

Magnetically Driven Hierarchical Alignment in Biomimetic Fibrous Hydrogels
W. Chen, Z. Zhang, P.H.J. Kouwer
Small 18, 2203033 (2022). [DOI: 10.1002/smll.202203033]

A temperature-based easy-separable (TempEasy) 3D hydrogel co-culture System
Z. Zhang, W. Chen, D.M. Tiemessen, E. Oosterwijk, P.H.J. Kouwer
Adv. Healthcare Mater. 11, 2102389 (2022). [DOI: 10.1002/adhm.202102389]

Cell-matrix reciprocity in 3D culture models with nonlinear elasticity
K. Liu, M. Wiendels, H. Yuan, C. Ruan, P.H.J. Kouwer
Bioact. Mater. 9, 316-331 (2022). [DOI: 10.1016/j.bioactmat.2021.08.002]

Rapid stem cell spreading induced by high affinity α₅β₁ integrin-selective bicyclic RGD peptide in biomimetic hydrogels
K. Liu, J. Vandaele, D. Bernhagen, M. Van Erp, E. Oosterwijk, P. Timmerman, S. Rocha, P.H.J. Kouwer
bioRxiv 2022.2002.2001.478177 (2022). [DOI: 10.1101/2022.02.01.478177]

2021

Fibrous Hydrogels under Multi-Axial Deformation: Persistence Length as the Main Determinant of Compression Softening
P. De Almeida, P.A. Janmey, P.H.J. Kouwer
Adv. Funct. Mater. 31, 2010527 (2021). [DOI: 10.1002/adfm.202010527]

Semiflexible polymer scaffolds: an overview of conjugation strategies
L. Gerrits, R. Hammink, P.H.J. Kouwer
Polym. Chem. 12, 1362-1392 (2021). [DOI: 10.1039/D0PY01662D]

Tunable Hybrid Matrices Drive Epithelial Morphogenesis and YAP Translocation
Y. Zhang, M.M.P. Zegers, A. Nagelkerke, A.E. Rowan, P.N. Span, P.H.J. Kouwer
Adv. Sci. 8, 2003380 (2021). [DOI: 10.1002/advs.202003380]

Multivalent Sgc8c-aptamer decorated polymer scaffolds for leukemia targeting
Z. Zhang, C. Tang, R. Hammink, F. Nelissen, H. Heus, P.H.J. Kouwer
Chem. Commun. 57, 2744-2747 (2021). [DOI: 10.1039/D0CC08205H]

Thin-Film Polyisocyanide-Based Hydrogels for Affinity Biosensors
D. Kotlarek, K. Liu, N.G. Quilis, D. Bernhagen, P. Timmerman, P. Kouwer, J. Dostalek
J. Phys. Chem. C 125, 12960-12967 (2021). [DOI: 10.1021/acs.jpcc.1c02489]

Structure and Dynamics of a Temperature-Sensitive Hydrogel
E.P. Van Dam, H. Yuan, P.H.J. Kouwer, H.J. Bakker
J. Phys. Chem. B 125, 8219-8224 (2021). [DOI: 10.1021/acs.jpcb.1c03121]

Magnetic Stiffening in 3D Cell Culture Matrices
W. Chen, Y. Zhang, J. Kumari, H. Engelkamp, P.H.J. Kouwer
Nano Lett. (2021). [DOI: 10.1021/acs.nanolett.1c00371]

Combining mechanical tuneability with function: Biomimetic fibrous hydrogels with nanoparticle crosslinkers
W. Chen, P.H.J. Kouwer
Adv. Funct. Mater. (2021). [DOI: 10.1002/adfm.202105713]

Probing Single-Cell Macrophage Polarization and Heterogeneity Using Thermo-Reversible Hydrogels in Droplet-Based Microfluidics
B.M. Tiemeijer, M.W.D. Sweep, J.J.F. Sleeboom, K.J. Steps, J.F. Van Sprang, P. De Almeida, R. Hammink, P.H.J. Kouwer, A.I.P.M. Smits, J. Tel
Front. Bioeng. Biotechnol. 9, 715408 (2021). [DOI: 10.3389/fbioe.2021.715408]

2020

Polyisocyanide hydrogels as a tunable platform for mammary gland organoid formation
Y. Zhang, C. Tang, P.N. Span, A.E. Rowan, G.J. Adema, P.H.J. Kouwer, M.M. Zegers, M. Ansems
Adv. Sci., 7, 202001797 (2020). [DOI: 10.1002/advs.202001797]

Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels
H. Yuan, Y. Zhan, A.E. Rowan, C. Xing, P.H.J. Kouwer
Angew. Chem. Int. Ed. 59, 2720-2724 (2020). [DOI: 10.1002/anie.201910979]
Angew. Chem. 132, 2742-2746 (2020). [DOI: 10.1002/ange.201910979]

Antimicrobial and anti-inflammatory thermo-reversible hydrogel for periodontal delivery
B. Wang, H.E. Booij-Vrieling, E.M. Bronkhorst, J. Shao, P.H.J. Kouwer, J.A. Jansen, X.F. Walboomers, F. Yang
Acta Biomater. 116, 259-267 (2020). [DOI: https://doi.org/10.1016/j.actbio.2020.09.018]

Synthetic Extracellular Matrices as a Toolbox to Tune Stem Cell Secretome” ACS Applied Materials and Interfaces
K. Liu, T. Veenendaal, M. Wiendels, A.M. Ruiz-Zapata, J. Van Laar, R. Kyranas, H. Enting, B. Van Cranenbroek, H.J.P.M. Koenen, S.M. Mihaila, E. Oosterwijk, P.H.J. Kouwer
ACS Appl. Mater. Interfaces 12, 56723-56730 (2020). [DOI: 10.1021/acsami.0c16208]

A tunable and injectable local drug delivery system for personalized periodontal application
B. Wang, J. Wang, J. Shao, P.H.J. Kouwer, E.M. Bronkhorst, J.A. Jansen, X.F. Walboomers, F. Yang
J. Control. Release 324, 134-145 (2020). [DOI: 10.1016/j.jconrel.2020.05.004]

Structural characterisation of fibrous synthetic hydrogels using fluorescence microscopy
J. Vandaele, B. Louis, K. Liu, R. Camacho, P.H.J. Kouwer, S. Rocha
Soft Matter 16, 4210-4219 (2020). [DOI: 10.1039/c9sm01828j]

Polyisocyanopeptide Hydrogels Are Effectively Sterilized Using Supercritical Carbon Dioxide
R.C. Op 'T Veld, M. Eerden, F. Wagener, P.H.J. Kouwer, J.A. Jansen, X.F. Walboomers
Tissue Eng. Part C Meth. 26, 132-141 (2020). [DOI: 10.1089/ten.tec.2019.0305]

Gel Casting as an Approach for Tissue Engineering of Multilayered Tubular Structures
M.J.J. Van Velthoven, R. Ramadan, F.S. Zügel, B.J. Klotz, D. Gawlitta, P.F. Costa, J. Malda, M.D. Castilho, L.M.O. De Kort, P. De Graaf
Tissue Eng Part C Methods 26, 190-198 (2020). [DOI: 10.1089/ten.TEC.2019.0280]

Biofabrication of a Functional Tubular Construct from Tissue Spheroids Using Magnetoacoustic Levitational Directed Assembly
V.A. Parfenov, E.V. Koudan, A.A. Krokhmal, E.A. Annenkova, S.V. Petrov, F.D.a.S. Pereira, P.A. Karalkin, E.K. Nezhurina, A.A. Gryadunova, E.A. Bulanova, O.A. Sapozhnikov, S.A. Tsysar, K. Liu, E. Oosterwijk, H. Van Beuningen, P. Van Der Kraan, S. Granneman, H. Engelkamp, P. Christianen, V. Kasyanov, Y.D. Khesuani, V.A. Mironov
Adv. Healthcare Mater. 9, 2000721 (2020). [DOI: https://doi.org/10.1002/adhm.202000721]

A minimally-invasive cryogel based approach for the development of human ectopic liver in a mouse model
J. Kumari, A.K. Teotia, A.A. Karande, A. Kumar
J. Biomed. Mater. Res. B Appl. Biomater. 108, 1022-1032 (2020). [DOI: 10.1002/jbm.b.34454]

2019

Cytoskeletal stiffening in synthetic hydrogels
P. De Almeida, M. Jaspers, S.L. Vaessen, O. Tagit, G. Portale, A.E. Rowan, P.H.J. Kouwer
Nat. Commun. 10, 609 (2019). [DOI: 10.1038/s41467-019-08569-4]. More info: Behind the paper; PhysicsWorld.

Synthetic extracellular matrices with nonlinear elasticity regulate cellular organization
K. Liu, S.M. Mihaila, A.E. Rowan, E. Oosterwijk, P.H.J. Kouwer
Biomacromolecules 20, 826-834 (2019). [DOI: 10.1021/acs.biomac.8b01445]. Liveslides summary.

Synthetic semiflexible and bioactive brushes
D. Voerman, M. Schluck, J. Weiden, B. Joosten, L.J. Eggermont, T. Van Den Eijnde, B. Ignacio, A. Cambi, C.G. Figdor, P.H.J. Kouwer, M. Verdoes, R. Hammink, A.E. Rowan
Biomacromolecules 20, 2587-2597 (2019). [DOI: 10.1021/acs.biomac.9b00385]

Monitoring 111In-labelled polyisocyanopeptide (PIC) hydrogel wound dressings in full-thickness wounds
R.C. Op't Veld, L. Joosten, O. Van Den Boomen, O. Boerman, P.H.J. Kouwer, E. Middelkoop, A. Rowan, J.A. Jansen, F. Walboomers, F. Wagener
Biomaterials Science 7, 3041-3050 (2019). [DOI: 10.1039/C9BM00661C]

2018

Crosslinking of fibrous hydrogels
D.C. Schoenmakers, A.E. Rowan, P.H.J. Kouwer
Nat. Commun. 9, 2172 (2018). [DOI: 10.1038/s41467-018-04508-x]. More info: Behind the paper.

Thermosensitive biomimetic polyisocyanopeptide hydrogels may facilitate wound repair
R.C. Op ‘T Veld, O.I. Van Den Boomen, D.M.S. Lundvig, E.M. Bronkhorst, P.H.J. Kouwer, J.A. Jansen, E. Middelkoop, J.W. Von Den Hoff, A.E. Rowan, F.a.D.T.G. Wagener
Biomaterials 181, 392-401 (2018). [DOI: 10.1016/j.biomaterials.2018.07.038]

Virus-like particles as crosslinkers in fibrous biomimetic hydrogels: approaches towards capsid rupture and gel repair
D.C. Schoenmakers, L. Schoonen, M.G.T.A. Rutten, R.J.M. Nolte, A.E. Rowan, J.C.M. Van Hest, P.H.J. Kouwer
Soft Matter 14, 1442-1448 (2018). [DOI: 10.1039/C7SM02320K]

Strong optical nonlinearities of self-assembled polymorphic microstructures of phenylethynyl functionalized fluorenones
X. Li, S. Semin, L.A. Estrada, C. Yuan, Y. Duan, J. Cremers, P. Tinnemans, P. Kouwer, A.E. Rowan, T. Rasing, J. Xu
Chin. Chem. Lett. 29, 297-300 (2018). [DOI: 10.1016/j.cclet.2017.11.001]

Tunable properties based on regioselectivity of 1,2,3-triazole units in axially chiral 2,2′-linked 1,1′-binaphthyl-based copolymers for ions and acid responsiveness
J. Lauko, P.H.J. Kouwer, P. Kasak, A.E. Rowan
Eur. Polym. J. 108, 191-198 (2018). [DOI: 10.1016/j.eurpolymj.2018.08.030]

Controlling the gelation temperature of biomimetic polyisocyanides
P.H.J. Kouwer, P. De Almeida, O. Ven Den Boomen, Z.H. Eksteen-Akeroyd, R. Hammink, M. Jaspers, S. Kragt, M.F.J. Mabesoone, R.J.M. Nolte, A.E. Rowan, M.G.T.A. Rutten, V.a.A. Le Sage, D.C. Schoenmakers, C. Xing, J. Xu
Chin. Chem. Lett. 29, 281-284 (2018). [DOI: 10.1016/j.cclet.2017.11.002]

2017

Liquid crystal templating as an approach to spatially and temporally organise soft matter
P. Van Der Asdonk, P.H.J. Kouwer
Chem. Soc. Rev. 46, 5935-5949 (2017).
[DOI: 10.1039/C7CS00029D]

Fully Stable and Homogeneous Lyotropic Liquid Crystal Alignment on Anisotropic Surfaces
P. Van Der Asdonk, P.J. Collings, P.H.J. Kouwer
Adv. Funct. Mater. 27, 1701209 (2017).
[DOI: 10.1002/adfm.201701209]

1H-1,2,3-Triazole: From Structure to Function and Catalysis
J. Lauko, P.H.J. Kouwer, A.E. Rowan
J. Heterocycl. Chem. 54, 1677-1699 (2017).
[DOI: 10.1002/jhet.2770]

Nonlinear mechanics of hybrid polymer networks that mimic the complex mechanical environment of cells
M. Jaspers, S.L. Vaessen, P. Van Schayik, D. Voerman, A.E. Rowan, P.H.J. Kouwer
Nat. Commun. 8, 15478 (2017).
[DOI: 10.1038/ncomms15478]

Muscovite mica as a growth template of PC61BM crystallites for organic photovoltaics
J. Feenstra, M. Van Eerden, A.K. Lemmens, W. De Poel, P.H.J. Kouwer, A.E. Rowan, J.J. Schermer
CrystEngComm 19, 4424-4436 (2017). [DOI: 10.1039/C6CE02492K]

Anchoring strength measurements of a lyotropic chromonic liquid crystal on rubbed polyimide surfaces
P.J. Collings, P. Van Der Asdonk, A. Martinez, L. Tortora, P.H.J. Kouwer
Liq. Cryst. 44, 1165-1172 (2017).
[DOI: 10.1080/02678292.2016.1269372]

Strategies To Increase the Thermal Stability of Truly Biomimetic Hydrogels: Combining Hydrophobicity and Directed Hydrogen Bonding
H. Yuan, J. Xu, E.P. Van Dam, G. Giubertoni, Y.L.A. Rezus, R. Hammink, H.J. Bakker, Y. Zhan, A.E. Rowan, C. Xing, P.H.J. Kouwer
Macromolecules 50, 9058-9065 (2017). [DOI: 10.1021/acs.macromol.7b01832]

Self-Healing Hydrogels Formed by Complexation between Calcium Ions and Bisphosphonate-Functionalized Star-Shaped Polymers
P.M. Lopez-Perez, R.M.P. Da Silva, I. Strehin, P.H.J. Kouwer, S.C.G. Leeuwenburgh, P.B. Messersmith
Macromolecules 50, 8698-8706 (2017). [DOI: 10.1021/acs.macromol.7b01417]

For a complete publication list of Alan Rowan and former members of the Molecular Materials, please click here (you will be directed to the AIBN website).