MED-B3KOF
Elective year 3, From mice to man: translating animal research into clinical benefit
Cursus informatieRooster
CursusMED-B3KOF
Studiepunten (ECTS)3
CategorieB3 (Derde jaar bachelor)
VoertaalNederlands
Aangeboden doorRadboud Universiteit; Faculteit der Medische Wetenschappen; Biomedische wetenschappen;
Docenten
Docent
dr. C.R. Hooijmans
Overige cursussen docent
Docent
dr. K.E. Wever
Overige cursussen docent
Examinator
dr. K.E. Wever
Overige cursussen docent
Contactpersoon van de cursus
dr. K.E. Wever
Overige cursussen docent
Collegejaar2024
Periode
S1-WOE  (02-09-2024 t/m 31-08-2025)
Aanvangsblok
S1-WOE
Onderwijsvorm
voltijd
Opmerking-
Inschrijven via OSIRISJa
Inschrijven voor bijvakkersNee
Voorinschrijving
WachtlijstJa
PlaatsingsprocedureOp basis van loting
ToelichtingOp basis van loting
Cursusdoelen
After completion of this course, you’ll be able to:
  1. Explain the current challenges in the translation of scientific results from animal studies to clinical practice and benefits for human health.
  2. Describe and reflect on factors which influence the relevance of animal studies for human health(care), such as reporting quality, internal validity and external validity.
  3. Reflect on current practice in preclinical animal research and describe the challenges and opportunities.
  4. Describe the methodology of systematic review of animal studies and the added value of this methodology for translating animal research into clinical benefit.
  5. Analyze and synthesize relevant information regarding the relevance and reliability of animal studies in a certain field of research, and give a well-informed personal opinion on the value of animal research for human health care.
  6. Describe the requirements needed to perform animal experiments in the Netherlands.
Inhoud
In this course you will gain a deep understanding of the value and limitations of animal research for human health(care). The role of animal research in e.g. drug development and toxicology is controversial: it is both championed as essential and criticised as unethical and ineffective. The ethical justification of animal studies critically relies on their expected contribution to improving human health - an expectation which is often unmet. Most therapies showing promising results in animals fail to translate to patients in terms of efficacy or safety. For instance, despite successful testing in animals, up to 85% of early clinical trials for novel drugs fail! Thus, translating animal data to humans is apparently not an easy task. How can the value of necessary animal studies be maximized?
 
In this course you will investigate the possible causes of translational failure when translating results from animal studies to humans. You will learn how to signal and prevent a variety of important limitations, biases and systematic failures in the use of animals as models for human disease. We will cover aspects of construct validity, internal validity, external validity, reporting quality, meta-research and we will discuss non-animal alternatives to animal models. You will work on case studies from disease areas such as stroke, Alzheimer’s disease, spinal cord injury, renal failure, MI and cancer. After this course you will be equipped to assess both the quality and robustness of an individual animal study, as well as that of an evidence base containing animal studies. Furthermore, you will have the knowledge needed to optimize the experimental setup of future animal studies.  
 
If you’d like to know more, or find out if this minor is right for you, please email your questions to kim.wever@radboudumc.nl
Key words
Animal research, synthesis of evidence, translational research, impact on health care.

 
Werkvormen
Cursus

Toetsen
Opinion paper / Pitch
Weging50
ToetsvormPaper
GelegenhedenBlok S1-WOE, Blok S1-WOE

Essay writing end
Weging50
ToetsvormEssay
GelegenhedenBlok S1-WOE, Blok S1-WOE

Reflection on group collaboration
Weging0
ToetsvormOpdracht
GelegenhedenBlok S1-WOE, Blok S1-WOE

Speed dating with animal researchers
Weging0
ToetsvormPracticum
GelegenhedenBlok S1-WOE, Blok S1-WOE