MED-B3MIN13
Medical biotechnology towards clinical practice
Cursus informatieRooster
CursusMED-B3MIN13
Studiepunten (ECTS)11
CategorieBA (Bachelor)
VoertaalEngels
Aangeboden doorRadboud Universiteit; Faculteit der Medische Wetenschappen; Biomedische wetenschappen;
Docenten
Examinator
dr. D.G. Wansink
Overige cursussen docent
Docent
dr. D.G. Wansink
Overige cursussen docent
Contactpersoon van de cursus
dr. D.G. Wansink
Overige cursussen docent
Collegejaar2024
Periode
S1-DOVR  (02-09-2024 t/m 31-08-2025)
Aanvangsblok
S1-DOVR
Onderwijsvorm
voltijd
Opmerking-
Inschrijven via OSIRISJa
Inschrijven voor bijvakkersNee
Voorinschrijving
WachtlijstJa
PlaatsingsprocedureOp basis van loting
ToelichtingOp basis van loting
Cursusdoelen
Main objectives

By the end of this course, you will be able to
  1  -  describe molecular and cellular principles of biotechnology
  2  -  describe the application of biotechnology to prevent, diagnose or treat human disease
  3  -  identify new developments in medical biotechnology
  4  -  design new strategies to use medical biotechnology in clinical practice
  5  -  recognize and evaluate ethical, regulatory and societal aspects of biotechnology in medicine
  6  -  carry out and understand biotechnological experiments and evaluate results critically
  7  -  work and collaborate effectively in a group
  8  -  effectively communicate scientific information orally and in writing
Inhoud
 
Medical biotechnology comprises the application of living cells or cell material in the development or generation of products to prevent, diagnose or treat human disease. Historical examples of biotechnology in support of medicine are the development of vaccines against smallpox and the production of antibiotics or human insulin by bacteria or yeast. Exciting 21st century developments are genetic engineering with CRISPR/Cas, gene therapy, mRNA vaccines against COVID-19 and stem cell-based regenerative medicine. Medical biotechnology is a fascinating and rapidly evolving field, integrating molecular, cell biological, genetic and immunological research areas.
The first part of this Minor runs together with the course NWI-MOL104 Medical Biotechnology for RU students from the Faculty of Science and provides an overview of how interdisciplinary efforts help shaping modern healthcare by developing biotechnological diagnostics and therapeutics for precision medicine. Principles and concepts of medical biotechnology will be discussed in a scientific and medical context, including legal, societal and ethical considerations. Together with students from different life sciences disciplines you will write a medical biotechnological research proposal and present this at a mini-symposium.
In the second half of the Minor you will carry out experiments in four different projects in the lab. These include molecular diagnostics (e.g., PCR, sequencing), recombinant DNA techniques, recombinant protein production, cell culture and adhesion assays, and cell transfection experiments mimicking gene therapy.
Altogether, Medical Biotechnology towards Clinical Practice presents an excellent practical and theoretical course for students interested in molecular life sciences and in biotechnological innovations for patient care.
For questions please do not hesitate to contact the coordinator at rick.wansink@radboudumc.nl.

Key words
Recombinant therapeutics, CRISPR/Cas, genetic engineering, gene therapy, vaccines, molecular diagnostics, biologics, stem cells, regenerative medicine, tissue engineering, immunotherapy

Relation
This Minor builds on prior molecular, cell biological, genetic and immunological knowledge provided in the Bachelor programs for Biomedical Sciences and Medicine.

Study path
The Minor contains plenary and interactive lectures, E-learning computer practicals, literature study, group presentations and tutor meetings to support the writing of a research proposal, and practical lab work combined with report writing and individual presentations.

Examination
Assessment consists of eight parts. Each must be graded at least 5.5 to pass the course, except for the written Q10 exam:
  1. Written exam Q9 (midterm; individual; weight 20%)
  2. Written mini-review and research proposal (group; weight 20%)
  3. Performance during research proposal writing (individual; weight 5%)
  4. Oral presentation of research proposal (group; weight 5%)
  5. Three written lab project reports (individual; total weight 35%)
  6. Oral presentation of lab project (individual; weight 10%)
  7. Performance during lab practicals (individual; weight 5%)
  8. Written exam Q10 (final; individual; pass/fail)
Literature
This Minor builds on background information in:
▪ Baynes / Dominiczak: Medical Biochemistry (5th ed., 2019)
▪ Alberts / Hopkin / Johnson / Morgan / Raff / Roberts / Walter: Essential Cell Biology (5th ed., 2019)
▪ Turnpenny PD, Ellard S: Emery's elements of medical genetics (16th ed., 2022)
▪ Parham: The Immune System (5th ed., 2021)
Links to additional study material (reviews, primary research papers) will be provided via  Brightspace.
Werkvormen
Werkgroep

Toetsen
Q9: Written exam
Weging20
ToetsvormTentamen
GelegenhedenBlok S1-DOVR, Blok S1-DOVR

Q9: Proposal - participation
Weging5
ToetsvormDeelname
GelegenhedenBlok S1-DOVR, Blok S1-DOVR

Q9: Proposal - writing
Weging20
ToetsvormOpdracht
GelegenhedenBlok S1-DOVR, Blok S1-DOVR

Q9: Proposal - presentation
Weging5
ToetsvormPresentatie
GelegenhedenBlok S1-DOVR, Blok S1-DOVR

Q10: Practicals - lab introduction and reporting
Weging0
ToetsvormVerslag
GelegenhedenBlok S1-DOVR, Blok S1-DOVR

Q10: Practicals - participation and performance
Weging5
ToetsvormPracticum
GelegenhedenBlok S1-DOVR, Blok S1-DOVR

Q10: Practicals - presentation
Weging5
ToetsvormPresentatie
GelegenhedenBlok S1-DOVR, Blok S1-DOVR

Q10: Practicals - written reports
Weging40
ToetsvormVerslag
GelegenhedenBlok S1-DOVR, Blok S1-DOVR