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After completion of the course, students are able to
- Understand the differences and communalities between various NDDs.
- Describe the genetic underpinnings of various NDDs.
- Understand the principles and virtues of generic profiling mnethodologies (Genetics, genomics, metabolomics)
- Describe the major molecular networks and cellular mechanisms that are disrupted in NDDs.
- Explain the possibilities and limitations of in vitro and in vivo models for neurobiological investigations into the mechanisms of disease.
- Reflect critically on scientific papers on topics covered in the course.
- Present a research paper and to give feedback on presentations of other students.
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The module
Neurodevelopmental disorders (NDDs) are a large group of cognitive, neurological, and psychiatric disorders that collectively have an unparalleled impact on our healthcare system. Despite considerable heterogeneity in main clinical features and comorbidities, communalities between individual disorders are also apparent. The overlapping spectrum of cognitive features in NDDs is reflected in the molecular and cellular underpinnings of these disorders. In this course, we aim to illuminate the genetic and environmental factors contributing to NDDs and to gain insight into the unique and common molecular and cellular mechanisms of their neuropathology. To that end, we will offer a program that will encompass: (i) standardized clinical and diagnostics protocols used in NDDs; (ii) the use of robust genetics, genomics and metabolomics profiling; (iii) the development and application of cell and animal disease models; (iv) the use of innovative behavioral, neurophysiological and neuroimaging protocols; (v) the development of strategies for therapeutic intervention.
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