Animal models for psychiatric and neurological disorders
Course infoSchedule
Course moduleMED-BMS30
Credits (ECTS)3
CategoryMA (Master)
Language of instructionEnglish
Offered byRadboud University; Faculty of Medical Sciences; Biomedische wetenschappen;
Contactperson for the course
prof. dr. J.R. Homberg
Other course modules lecturer
prof. dr. J.R. Homberg
Other course modules lecturer
Academic year2017
3  (30/10/2017 to 26/08/2018)
Starting block
Course mode
RemarksPeriod 3a, Monday and Tuesday
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registration openfrom 01/04/2017 up to and including 02/10/2017
Waiting listYes
Placement procedureDone manually by Back Office
ExplanationDone manually by Back Office
The main objectives of this module are:
After completion of the course, students are able to:
  1. define technologies to generate and method to breed transgenic animals
  2. define which behavioural models for rodents measure what type of behaviour and how they work
  3. define animal models for disease and aware of their advantages and disadvantages
  4. explain how neurotechnologies and ex vivo technologies work
  5. design experiments dedicated to test a hypothesis
  6. evaluate experiments as presented in papers
The module 

Animal experimental research is essential to increase our fundamental understanding of brain structure and function, to answer mechanistic questions that cannot be addressed in humans, and to test the efficacy of new interventions or treatments. In this course we aim to get student acquainted with practical and translational issues related to animal experimental research. First, we discuss practicalities regarding rodent models; how to generate, obtain and maintain transgenic mice and rats. Second, we present several behavioural methods to model endophenotypes of stress-related, neurodevelopmental and neurological disorders, and we discuss their translational value. Third, we present a variety of noninvasive and invasive neurotechnologies to link behaviour to brain function and to manipulate brain function in a precise manner. Fourth and last, we discuss methods to sacrifice animals and methodologies to assess brain function ex vivo.

Instructional modes
Working group

Period 3a, Monday and Tuesday

Course examination
Test weight1
OpportunitiesBlock 3, Block 3