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The main objectives of this module are:
After completion of the course, students are able to
- define which forms of cell death exist
- explain how these forms of cell death are regulated
- apply knowledge of mechanisms of cell death regulation to develop predictive biomarkers for cancer therapies
- distinguish between necrosis, apoptosis, autophagy, ferroptosis
- design treatment protocols that can induce cell death in cancer
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The module
Without cell death, life of multicellular organisms is impossible. Induced cell death is crucial for embryonic development and in immunity. On the other hand, if cell death is improperly regulated it may result in disease, such as autoimmune disease, chronic viral infection and cancer.
This course focuses on mechanisms of cell death in life and disease. A better understanding of the molecular biology and cell biology principles that are involved in cell death allows us to influence the process resulting in specific treatment of disease. Special attention will be given to deregulated cell death in cancer.
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