MED-BMS40
Nanomedicine
Course infoSchedule
Course moduleMED-BMS40
Credits (ECTS)3
CategoryMA (Master)
Language of instructionEnglish
Offered byRadboud University; Faculty of Medical Sciences; Biomedische wetenschappen;
Lecturer(s)
Contactperson for the course
prof. dr. A. Cambi
Other course modules lecturer
Examiner
prof. dr. A. Cambi
Other course modules lecturer
Academic year2017
Period
7  (05/03/2018 to 26/08/2018)
Starting block
7
Course mode
full-time
RemarksPeriod 7a, Monday and Tuesday
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationYes
Pre-registration openfrom 01/04/2017 up to and including 05/02/2018
Waiting listYes
Placement procedureDone manually by Back Office
ExplanationDone manually by Back Office
Aims
The main objectives of this module are:
 
After completion of the course, students are able to
  1. define   strategies   to   create   multifunctional   molecular   assemblies   to   exploit   specific characteristics of cells/tissues for targeting
  2. explain how the interplay of nanomedicine and cell biology leads to drug delivery
  3. perform a critical review of nanomedicine literature with respect to the significance of the study to provide a novel treatment
  4. design  nanomedicine  strategies  based  on  the  understanding  of  the  specific  molecular characteristics of cells and tissues
  5. evaluate experimental nanomedicine strategies with respect to their potential clinical value
Content
The module 

Nanomedicine aims to create molecular functional units on the nanoscale for use in disease treatment and diagnostics. In treatment, the motivation is to deliver a drug specifically to the site of action, thereby increasing efficiency, reducing side effects and make classes of drugs accessible that, unless incorporated into a delivery vehicle, are rapidly degraded  inside the body.  A prominent example is siRNA to reduce expression of certain target genes. In diagnostics, nanomedicine creates probes to detect cancer or report on the metabolic situation in certain tissues. The design of nanomedicines is frequently guided by nature as exemplified by drug delivery systems that mimic the function of viruses.
Nanomedicine is multidisciplinary, ranging from bioorganic chemistry, to cell biology and histology. Bioorganic chemistry links individual building blocks into multifunctional molecular assemblies. Cell biology defines the molecular interaction of nanomedicines with cells and how this leads to delivery of a nanomedicine at a certain location inside the cell. Histology creates the basis for specificity for certain cell types.
This course will teach the key concepts of nanomedicine covering the following topics:
  • Bioconjugation strategies for the generation of (macro-)molecular assemblies
  • Detection modalities (Fluorescence/radioactivity)
  • Principles of nanoscale cell biology and histology of targeting and drug delivery
  • Nanoparticles for drug delivery/liposomes
  • Organ-on-the-chip
Levels
master

Instructional modes
Working group

Remark
Period 7a, Monday and Tuesday

Tests
Course examination
Test weight1
OpportunitiesBlock 7, Block 7