The main objectives of this module are:

 

After completion of the course, students are able to

1. define the key molecular mechanisms that regulate targeted cellular processes (metabolism, cell migration and stem cell differentiation);
2. explain the various phases of the drug development pipeline;
3. apply  the  knowledge  of  these  cellular  processes   to  the  understanding  of  the  working mechanisms of related therapeutics
4. analyze the way in which the development of therapeutics is different in each of the three pillars of medicine
5. evaluate the different drug development schemes

The module 

This course focuses on the three pillars of medicine: the classical small molecules, the newer biologics and the most recent cell-based therapeutics. The classical drug development pipeline will be illustrated by focusing on targeting metabolism by means of small molecules. Next, the students will identify differences in the development of biologics as compared to small molecules. The biologics that will be studied are used in inflammation and cancer to target cell migration. The challenges of the cell-based therapeutics will be analyzed in the context of stem cell differentiation for regenerative medicine and in anti-cancer immunotherapy.
Students will be introduced into the relevant topics by means of self-study, interactive lectures, team-based learning sessions and challenge sessions/journal clubs with experts in the field. Two practical assignments aim at providing hands-on experience.
 
This course potentially links to the following other courses in the BMS master curriculum: 40; 41; 43; 48; 64; 65.