The main objectives of this module are:
After completion of the course, students are able to
- define (knowledge) the various molecular mechanism that underlie different disorders of movement
- explain (comprehension) the differences and overlap between the various disorders of movement, at the level of mechanisms, symptoms and treatment
- distinguish (analysis) the various clinical symptoms and diagnostic strategies associated with disorders of movement
- evaluate (evaluation) commonly used principles in treatment of movement disorders
- write a concise report about either a molecular, symptomatic, or treatment issue with a focus on the commonalities between different disorders.
This course focuses on an integrated approach of the molecular mechanisms, clinical symptoms and treatment of neurodegenerative and neuromuscular disorders of movement. Current insight into the variety of movement disorders reveals that, unlike the distinct labels of specific diseases, many of these disorders show overlap in the molecular mechanisms that cause the disease, in clinical symptoms, but also in the way the different disorders are being treated. This course aims to provide an integrative insight into the heterogeneities and commonalities among these disorders of movement at the three levels of mechanisms, symptoms and treatment of disease. The focus of the course will be on some common movement disorders such as Parkinson’s disease, but also on more rare genetic disorders such as ataxia and rare neuromuscular disorders such as facioscapulohumeral muscular dystrophy (FSHD) and Duchenne’s muscular dystrophy.