In this module the student will:
1. learn about processes where migration plays a role in general
2. learn to discriminate migration modes
3. study the role of dysregulated cell migration in the cancer progression cascade and how cell migration is
therapeutically used
4. study different types of migration models and microscopy applicable for the study of cell migration
5. start together a small migration experiment, and inspect different migration models
6. prepare a practicum report
7. practice to (critically) read and report about a publication from the cell migration field
8. overall, receive a theoretical and experimental introduction to the field of cell migration.
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Cell migration is a fundamental physiological process during embryonic development, immune response and wound healing of the human body. The intrinsic capacity of normally resident adult tissue cells to migrate upon activation can be “mis-used” in certain diseases, for example in cancer, where cell motility can contribute to cancer metastases and mortality.
This course will start with a small repetition and question/ answer hour from the ‘Van cell naar weefsels’ part of the Q2 Nature module which has offered basic cell biological knowledge on how a healthy cell, alone or in a tissue context, is built, functions molecularly, and looks under the microscope. Continuing from there, the students will learn about the molecular basis of cell migration and how it is linked to deregulated migration, but also how therapy approaches could be developed. Students will be offered lectures and E-learning, will study migrating cells in a small hands-on part, report to each other about this practicum, as well as will prepare a journal club.
The motivation to offer this elective lies in the desire to make students in the biomedical field better understand how physiological processes are regulated, but also underlie disease mechanisms.
Doelgroep
This module fits particularly well to second-year BMW students, because this elective contains a small experimental part. But second-year medical and dental students are welcome as well!
Required prior knowledge
The here offered Q6 module will deal with the dynamic aspect of a (cancer) cell. Participation in this module will deepen and broaden, and thus form an excellent extension of, already acquired knowledge on the topics of cell biology, and on cancer. Particularly well-suited preparation courses are the a) Q2 MGZ modules (2MGC, 2MGX, 2MCB, 2MCW), which have offered basic cell biological knowledge on how a healthy cell, alone or in a tissue context, is built, how it functions molecularly, and how it looks like at microscopic resolution; and b) the Q5 module on cancer development (MG7).
Module opzet / tijdschema
Course languages will be both English and Dutch.
50 study hours (10 weeks á 5 hours. 1 hour (h) means 45 min+15 min break):
16.5 contact hours (1/3 of the hours), 33.5 self study hours (2/3of the hours)
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