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After completion of the Minor, students are able to
- Understand the concept of risk markers, risk factors and modulating factors for development of atherosclerosis and heart failure.
- Describe the molecular and cellular pathophysiology of atherosclerosis and heart failure, understand the pathophysiology of the most important risk factors for these diseases and are able to use this knowledge to generate new concepts for treatment and prevention.
- Explain the impact of adaptive and maladaptive responses on end-organ damage and are able to use this knowledge to generate new concepts for its prevention.
- Explain tools to study the pathophysiology of atherosclerosis and heart failure from molecule to population and are able to apply this knowledge to develop new research proposals that translate concepts and observations between two of the three areas of research (preclinical, clinical and population research).
- Design an original research proposal in the above identified main areas of cardiovascular medicine (atherosclerosis, heart failure) and present its background, hypothesis, objectives and methods in a concise report.
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This Minor focuses on atherosclerosis and heart failure, main causes of death and reduced quality of life globally. These are also main topics of research within the research theme Cardiovascular Damage at Radboudumc. This minor will bring you in contact with investigators from this theme and related themes and will prepare you for a bachelor research fellowship within the research facilities of these investigators. In addition, this minor gives you the opportunity to follow an introduction course in regulations and organization of human (clinical) research, knowledge that is essential to perform studies in humans or with material sampled from humans. Both atherosclerosis, heart failure and its important risk factors (hypertension, diabetes, hyperlipidemia) will be introduced by lectures and (sel)study assignments focusing on the pathobiology, pathophysiology and epidemiology of these disorders. Some monogenetic diseases associated with heart failure (glycosylation disorders and mitochondrial diseases) will also be discussed to facilitate an in depth knowledge of metabolic modulation of cardiac function and (mal)adaptive processes that can prevent or enhance cardiac dysfunction. Subsequently, you will collaborate in research teams of 3-4 students to investigate these topics further in self study assignments and interactive lectures. Areas of uncertainty will be identified and these will be selected by teams for further literature searches that will be reviewed by these teams in plenary meet-the-expert sessions. Coached by investigators/faculty members, each team will use one of these reviews to design a research protocol that should solve some of the identified uncertainty. This research should have a translational character, that means: it translates between levels of complexity from molecule to population and back. The final goal of the proposed research should be to improve personalized prevention and treatment of atherosclerosis or heart failure.
Key words
Atherosclerosis, Myocardial Infarction, Heart Failure, Risk factors.
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