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After completion of the Minor, students are able to:
- Understand the clinical impact and unmet diagnostic and therapeutic needs for the most prevalent as well as rare renal diseases.
- Understand and apply clinical chemical aspects of key analytical methods for the diagnosis and monitoring of patients with renal diseases.
- Visualize and interpret renal tissue markers using an (immuno)histological approach for the diagnosis of patients with renal diseases.
- Understand and execute molecular and immunological diagnostic methods for the diagnosis of renal diseases.
- Formulate a relevant clinical/fundamental research question, develop a study design and execute the experiments needed to address this question on an individual base.
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Each day, 180 liters of plasma is filtered by your kidneys to remove waste products from the circulation and maintain volume homeostasis. Around 99% of this filtrate/pro-urine is reabsorbed within the kidney via various transport processes, making the kidney a true hub of activity. A vast number of factors governs transport in the kidney, many of which are still largely unknown to us.
This is where you come in! In this minor, you will adopt the role of a renal researcher, attempting to answer questions like: Can we come up with alternatives to kidney transplants? What is the link between hypertension and kidney disease? Which cells are involved in scar-formation in focal segmental glomerulosclerosis? How does the kidney regulate excretion of magnesium and calcium, even though dietary intake varies wildly? How accurate and precise are the diagnostic tools that we currently have, and can we improve them?
In addition, there will be multiple opportunities to discuss the impact of renal disease with patients suffering from kidney diseases. What is it like to receive a renal transplant? What is the impact of having to travel to the dialysis ward almost every day?
This will provide you with the framework you need to set up and conduct your very own experiments at the one of the Radboudumc departments with ongoing ground-breaking renal research programs.
Over the course of several weeks, you will function as a PhD student at such a department, and hopefully add exciting new knowledge on renal disease mechanisms and associated leads for novel diagnostic tools or treatment targets kidney. You will present your newly found data to the other researchers at the department and in a scientific article.
Taken together, this minor introduces you to current topics in renal disease, using a bench-to-bedside approach. A variety of lab, diagnostics, clinical and social experiences will help you gain a better understanding of the connection between fundamental kidney research and clinical practice. And will let you experience top-notch research first-hand to prepare you for your bachelor internship.
Key words
Kidney, physiology, genetics, pathology, clinical chemistry, molecular biology, research, biomarkers
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