MED-MIN21
Breast cancer; biology, treatment, patient
Cursus informatieRooster
CursusMED-MIN21
Studiepunten (ECTS)12
CategorieBA (Bachelor)
VoertaalEngels
Aangeboden doorRadboud Universiteit; Faculteit der Medische Wetenschappen; Biomedische wetenschappen;
Docenten
Contactpersoon van de cursus
dr. M.M.P. Zegers, PhD
Overige cursussen docent
Examinator
dr. M.M.P. Zegers, PhD
Overige cursussen docent
Collegejaar2022
Periode
MIN-DOVR  (05-09-2022 t/m 31-08-2023)
Aanvangsblok
MIN-DOVR
Onderwijsvorm
voltijd
Opmerking-
Inschrijven via OSIRISJa
Inschrijven voor bijvakkersJa
Voorinschrijving
WachtlijstJa
PlaatsingsprocedureOp basis van loting
ToelichtingOp basis van loting
Cursusdoelen
After completion of the minor, students
  • Are able to define the main molecular mechanisms involved in normal breast development and breast cancer, and to use this knowledge to explain concepts underlying general and personalized anti-tumor therapy.
  • Can evaluate in vivo and in vitro model systems to investigate breast cancer biology and therapy.
  • Have an overview of the main types of breast cancer diagnosis, biobanking, breast cancer patient screening, and treatment.
  • Have acquired practical skills (e.g. pipetting, immunofluorescence, qPCR, cell culture, SPSS) aimed at investigating tumorigenesis and therapy, and to use this, in combination with the theoretical knowledge also obtained in this minor, to perform an experiment, interpret the results, and draft a report on the effect of treatment and hypoxia on breast cancer cells and in patients
  • Have been trained in writing a research proposal
Inhoud
About 14,000 women (and 100 men) are diagnosed with invasive breast cancer each year in the Netherlands, which means that 12-13% of women will develop breast cancer at any time in her life. Early detection, particularly via national breast cancer screening, combined with locoregional treatment and systemic adjuvant therapy has improved the prognosis in women with breast cancer (Breast Cancer Guideline, NABON 2012). In this minor, we will use breast cancer as example to understand the many factors that determine successful translational research on a human disease. Breast cancer is a good example for this approach as it is major cause of mortality, and a well-studied disease with various underlying molecular defects to which targeted therapies can be designed. Furthermore, breast cancer patient support and advocacy groups are relatively large and well-organized and are an important factor in research fund raising.
 
The main aspects covered in this minor include the following:
  • The molecular mechanisms that cause the disease
  • Preclinical cell and animal models to study the disease and to predict therapeutic efficacy
  • Methods for diagnosis, and to design targeted and personalized treatment
  • How to monitor efficacy of therapy?
  • Patients-involvement in decision making?
  • How to write a research proposal

Further information can be obtained by e-mailing the coordinators Mirjam Zegers (mirjam.zegers@radboudumc.nl) and Paul Span (Paul.span@radboudumc.nl).  

Key words
Cancer biology, cancer diagnostics and screening, histopathology, cancer therapies.

Important point
Participation is obligatory for all lectures, workgroups/assignments and practicals.  In case of absence for valid reasons (i.e, sickness or other emergencies), the minor coordinators should be contacted to discuss alternatives.
Niveau

Voorkennis

Toetsinformatie

Bijzonderheden

Werkvormen
Werkgroep

Toetsen
Practicum Report 2
Weging15
ToetsvormVerslag
GelegenhedenBlok MIN-DOVR, Blok MINK

Exam
Weging50
ToetsvormTentamen
GelegenhedenBlok MIN-DOVR, Blok MINK

Portfolio
Weging20
ToetsvormPortfolio
GelegenhedenBlok MIN-DOVR, Blok MINK

Grant proposal
Weging15
ToetsvormVerslag
GelegenhedenBlok MIN-DOVR, Blok MINK