MED-MM1MC
Masterclass 1
Course infoSchedule
Course moduleMED-MM1MC
Credits (ECTS)1.5
CategoryMA (Master)
Language of instructionEnglish
Offered byRadboud University; Faculty of Medical Sciences; Molecular Mechanisms of Disease;
Lecturer(s)
Contactperson for the course
dr. M. Verdoes
Other course modules lecturer
Examiner
dr. M. Verdoes
Other course modules lecturer
Academic year2017
Starting block
1
Course mode
full-time
Remarks-
Registration using OSIRISNo
Course open to students from other facultiesNo
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
 
Content
MMD Masterclass Chemical Immunology
Masterclass in Infection, Immunity and Regenerative Medicine/Immunity-related Disorders and Immunotherapy (MM1MC) – September 25-29 (week 39), 2017.
Coördinators: Martijn Verdoes and Carl Figdor, Dept. Tumor Immunology.
 
Summary

Immunology? It’s all about chemistry!
Antigen presentation, immune cell activation, cell migration and target cell killing are just a few examples of important immunological processes which are regulated by chemistry. The research field of Chemical Immunology applies chemistry to study molecular mechanisms and chemical processes in immunology and is currently gaining momentum. More importantly, the knowledge obtained at the interface of these two seemingly unrelated disciplines forms the basis of the development of novel breakthrough therapies for immune disorders and cancer: The understanding of the chemistry of immunology allows for the modulation of its molecular mechanisms by custom designed and synthesized molecules. This Masterclass will provide detailed knowledge of the molecular basis of several important immunological concepts which are controlled by chemical processes. Moreover, during the course there will be an emphases on the cutting edge of cancer immunotherapy from molecular design to clinical application, and the development of new chemical approaches to study and modulate immunology which greatly contributes to the advancement of our understanding of health and disease.

Monday
- General lectures: three lectures introducing different aspects of Chemical Immunology, presented by local experts.

Tuesday
- Workgroups to prepare for journal club and chairing of the symposium sessions.

Wednesday
- Journal club discussing paper(s) from invited speakers
- Meet & Greet with the speakers.
- Mini Symposium day 1

Thursday
- Journal club discussing paper(s) from invited speakers
- Meet & Greet with the speakers
- Mini Symposium day 2

Friday
- Self-study Assignment (individual): Write a Meeting report (opinion) about the MMD masterclass Symposium discussing the highlights of the lectures and placing it in the context of chemical immunology based on the knowledge from the General lectures and literature.

Potential topics/speakers:
Chemical and molecular mechanisms in immunology.
- Antigen presentation: proteolysis, epitope selection, routing, presentation (Prof. J. Neefjes, Dr. S. van Kasteren).
- Bittersweet immunology: the role of sugars in tumor immunology (Prof. Y. van Kooyk, C. Büll).
- “Who, what, where and when” of immune activation (Prof. A. Esser-Kahn).
Chemical Immunology: chemical and molecular approaches to study immunology and to improve therapy.
- Artificial antigen-presenting cells (Prof. C. Figdor).
- Synthetic immune-niches (Prof. D. Mooney).
- Synthetic vaccines (Dr. M. Verdoes, Prof. K. Melief).
- Conditional MHC class I ligands and their application in immunotherapy (Prof. T. Schumacher).
- Small molecule immunomodulators to restore immune control of cancer (Prof. B. van den Eynde).
Literature
selected articles (announced on Blackboard)

Additional comments
This course is aimed at students of the MSc programme Molecular Mechanisms of Disease, who started in September 2015. The course is also open to RIMLS PhD students. For attendance please contact the programme coordinator (helma.pluk@radboudumc.nl).

Topics
Imaging, MRI, PET, ultrasound, SPECT, cell therapy, dendritic cells, stem cells This unique component of the MSc MMD is dedicated to topics within the main themes of the programme and the RIMLS. Distinguished researchers from international partner universities present the latest research developments in their field, introducing new research topics and challenging questions.

Levels
2nd year MSc MMD

Test information
Assessment will be carried out on the basis of:

• Presentation of journal club paper
• Preparation of questions to speakers of the journal club
• Participation in discussion with guest speakers
• Participation in the symposium
• Written Assignment

Prerequisites
The modules MM1CF and MM1TR (or equivalent) are required for this course.

Tests
Tentamen
Test weight1
OpportunitiesBlock 1, Block 1