NWI-BB019B
Immunology
Course infoSchedule
Course moduleNWI-BB019B
Credits (ECTS)6
CategoryBA (Bachelor)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
Lecturer(s)
Coordinator
prof. dr. J. van der Vlag
Other course modules lecturer
Lecturer
prof. dr. J. van der Vlag
Other course modules lecturer
Contactperson for the course
prof. dr. J. van der Vlag
Other course modules lecturer
Academic year2017
Period
KW2  (13/11/2017 to 04/02/2018)
Starting block
KW2
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listYes
Placement procedureDone manually by Back Office
ExplanationDone manually by Back Office
Aims

Learning objectives (reached at the end of the course):

  • Using the basal immunological principles, you can precisely identify, and eventually design, molecular and cellular targets of immunotherapeutics that can be applied to restore the balance of the immune system in the case of allergy, autoimmunity, graft rejection, infection and cancer.
  • Using the basal immunological principles, you can describe and reason, in molecular and cellular detail, how the balance of the immune system is disturbed in the case of allergy, autoimmunity, graft rejection, infection and cancer. 
  • You can describe in molecular and cellular detail the roles of humoral and cellular immunity in the effector phase of an immune response.
  • After encounter by the immune system of an antigen, you can describe in molecular and cellular detail how an initial immune response is regulated, and you can reason how an initial immune response may lead to either immunity or tolerance.
  • You know all the differences between the innate and adaptive immune system, and you can describe in molecular and cellular detail the interaction between the innate and adaptive immune system, during an immune response.
  • You can fully describe the tissues, cells and humoral components of the healthy immune system in the human body.
Content
Themes:

1             Introduction immune system
2             Innate immunity
3             MHC complex structure and function, and antigen processing
4             B cell development, B cell receptor and antibodies
5             T cell development and T cell receptor
6             Immune cell receptors, ligands and signal transduction
7             Cellular immunity
8             Humoral immunity        
9             Infection & immunodeficiency’s
10           Tumor immunology
11           Tolerance and autoimmunity
12           Transplantation immunology
13           Manipulation of the immune reaction
 
Literature
Obligatory:

• A.K. Abbas, A.H. Lichtman, and S. Pillai, Cellular and Molecular Immunology
(9th Edition), Elsevier 2018, 608 pp, ISBN: 9780323479783. Costs: ~Euro 80.
• Module guide "Immunology" (course committee Immunology Radboudumc; coordinator
Dr. J. van der Vlag). Costs: ~5 Euro.
• For the wet practical training a laboratory coat.

Teaching formats
• 10 hours computer assignments
• 4 hours E-learning
• 14 hours lectures
• 14 hours responsive lectures
• 11 hours Laboratory course
• 114 hours individual study period

Additional comments
• This course will be taught in English.
• The course is teached on Mondays and Tuesday in the given period.
• The number of participants is maximized to 135.
• The graded assignments (2 wet practical assignments, 2 computer assignments (COO), and the literature assignment) are obligatory.

Please note that due to the preparations of the practical part, you need to register for this course at least 4 week before the start.

Topics
• Introduction immune system
• Innate immune system
• MHC complex structure and function, and antigen processing
• B cell development, B cell receptor and antibodies
• T cell development and T cell receptor
• Immune cell receptors, ligands and signal transduction
• Cellular immunity
• Humoral immunity
• Infection and immunodeficiencies
• Tumor immunology
• Tolerance and autoimmunity
• Transplantation immunology
• Manipulation of the immune reaction
• Immunological techniques

Test information
Grading is based on practical assignments (25%) and a final multiple choice test (75%).

Prerequisites
Basic cell - Moleculaire Biology as taught in: NWI-BP010B Moleculaire Biologie & Recombinant DNA

Required materials
Book
A.K. Abbas, A.H. Lichtman, and S. Pillai, Cellular and Molecular Immunology (9th Edition), Elsevier 2018, 608 pp
ISBN:9780323479783
White coat
Reader
Immunology

Instructional modes
E-learning

Lab course
Attendance MandatoryYes

Lecture

Practical computer training
Attendance MandatoryYes

Response course

Self study

Tests
Tentamen
Test weight1
OpportunitiesBlock KW2, Block KW4