Animal Cell Biology
Course infoSchedule
Course moduleNWI-BB023B
Credits (ECTS)6
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
PreviousNext 1
dr. J.H.A. Martens
Other course modules lecturer
dr. J.H.A. Martens
Other course modules lecturer
dr. J.H.A. Martens
Other course modules lecturer
Contactperson for the course
dr. J.H.A. Martens
Other course modules lecturer
dr. J.H.A. Martens
Other course modules lecturer
Academic year2018
KW3  (28/01/2019 to 07/04/2019)
Starting block
Course mode
Registration using OSIRISYes
Course open to students from other facultiesYes
Waiting listYes
Placement procedure-
  1. Upon completion of the course the student has knowledge of and insight into the following fundamental cell biological processes in animal cells at the level of the main molecular components and regulators involved:
    • Cell communication and signal transduction (nuclear response, regulation of the cell cycle and cell differentiation)
    • Protein sorting and intracellular transport
    • Regulation and function of the cytoskeleton in cell morphology, intracellular transport, cell migration and mitosis
    • Integration of cells in tissues, and the functions of cell adhesion and extracellular matrix proteins
  2. Upon completion of the course, the student understands how the above processed functionally interact and how they are involved in human diseases, particularly the onset and progression of cancer
  3. Upon completion of the course the student masters practical skills required to implement basic cell culture techniques and can independently apply these skills, in combination with the above theoretical knowledge, to design, perform and report upon an experiment aimed at testing a specific hypothesis on the mechanism of cell adhesion
  4. Upon completion of the course the student can apply the molecular and cell biological knowledge to the extent required to describe the physiological function of molecular components and regulators of the cell biological processes mentioned above
  5. Upon completion of the course the student will be able to place scientific literature in English into the context of the knowledge gained in the course and to apply this literature, with a team of fellow students,  towards a presentation in which the relationship between the mutation or defect of a single gene product, and the pathophysiology of a resulting humane monogenetic disease is described.

The lectures will cover:

  1. Regulation of the cell cycle
  2. Growth factors and receptors
  3. Signal transduction (protein kinases, second messengers, nuclear response)
  4. Tumorigenesis (initiatie, promotie, progressive, oncogenes and tumorsuppressor genes)
  5. Stem cells (embryonic, adult, cancer stem cells, induced pluripotent)
  6. Protein sorting (signal sequence, membrane topology, ER quality control, glycosylation)
  7. Vesicular transport
  8. Cytoskeleton (functions in cell morphology, cell migration and mitosis)
  9. Cell adhesion
  10. Extracellular matrix

Experimental work will include cell culture and experiments on the interaction of cells with extracellular matrix

Group projects will be focused on human diseases that originate from mutations or deregulated expression of proteins involved in cell biological processes covered in this course.

Additional comments
contact: J. Martens (j.martens@ncmls.ru.nl)
Course will be given on Mondays and Tuesdays

IMPORTANT: Because of the preparations for the practicum, signup for the course 4 weeks before the start at the latest.

Test information
Written Exam (minimum grade of 5.5, counts 70%); Report of the laboratory assignment (minimum grade of 5.5, counts 10%); Presentation (minimum grade of 5.5, counts 20%)

General phase of study Biology of Molecular Life Sciences

Recommended materials
Lodish et al., 'Molecular Cell Biology', 6e ed. 2007, W.H. Freeman & Company, UK
Course guide
Laboratory course guide

Instructional modes
Course occurrence

Lab course + lecture
Attendance MandatoryYes


Attendance MandatoryYes

Attendance MandatoryYes



Test weight7
Test typeExam
OpportunitiesBlock KW3, Block KW4

Test weight1
Test typeReport
OpportunitiesBlock KW3, Block KW4

Test weight2
Test typePresentation
OpportunitiesBlock KW3, Block KW4