Principles and Practice of Human Pathology
Course infoSchedule
Course moduleNWI-BB025B
Credits (ECTS)6
Category03 (Advanced)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
G.J.M. Smeets
Other course modules lecturer
G.J.M. Smeets
Other course modules lecturer
Contactperson for the course
G.J.M. Smeets
Other course modules lecturer
G.J.M. Smeets
Other course modules lecturer
Academic year2022
KW3  (30/01/2023 to 09/04/2023)
Starting block
Course mode
Registration using OSIRISYes
Course open to students from other facultiesYes
Waiting listNo
Placement procedure-
Human pathology is the study of disease processes. Central issue in this course is the way a living organism reacts to an injurious agent. The resulting pathophysiological and cell biological processes will be discussed and illustrated by means of a limited number of relevant examples. As adaptive and pathological changes in one organ(system) very often results in morphological and functional changes in other organs, we will also pay attention to these chain reactions as ‘multi-organ thinking’.
This course provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and diagnostic medicine. Obtained knowledge and skills will prepare students for employment in o.a. research institutes for (molecular) life sciences and diagnostic laboratories of academic hospitals.
The student has to become familiar with the advanced clinicopathologic foundations of medicine through the study of selected topics.  Following introductory lectures, the subject matter will be studied according to the principles of blended learning, meaning: small group learning, flipped the classroom sessions and practical courses. Additionally, the student has gained insight into the position of the biomedical scientist in relation to basic science and clinical practice.

After completing the course, the student should be able to demonstrate an advanced knowledge level of:
  1. the terminology used in human pathology (the field of Medical Sciences).
  2. the morphology of normal tissues and organs – both gross and microscopic.
  3. the relationship between human pathology and (microscopic) changes in tissue architecture.
  4. principal (patho)physiologic processes including: (1) the mechanisms of cellular adaptation, cell injury and cell death (2) inflammation, (3) neoplasia, (4) nephropathology, (5) 'Artificial Intelligence' (AI) for Health.
Presumed foreknowledge
Knowledge on: cell biology, cytology, histology, human biology, and (basal) pathology.
Test information
The multiple choice digital exam will test the knowledge and insight on the information collected during the course. The grade for the exam is the final grade. As you can only define how different the status of a an organism (pathology) is when compared to normal homeostasis, knowledge of normal functional histology and human biology will be included in the exam.
Recommended materials
Rubin and Reisner, (Essentials of) Rubin's Pathology, Lippincott-Williams & Wilkins; Philadelphia
(Wheather's) Functional Histology - Young et al. OR Junqueira et al.
Learning Management System (Brigthspace)
Additional course content will be available on Brightspace (e.g. reader, practicals).

Instructional modes
Attendance MandatoryYes

Practical computer training
Attendance MandatoryYes

Digital Exam
Test weight1
Test typeDigital exam with CIRRUS
OpportunitiesBlock KW3, Block KW4