NWI-BB065B
Pathophysiology of the Kidney
Course infoSchedule
Course moduleNWI-BB065B
Credits (ECTS)6
Category-
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
Lecturer(s)
PreviousNext 5
Coordinator
dr. J.H.F. de Baaij
Other course modules lecturer
Lecturer
dr. J.H.F. de Baaij
Other course modules lecturer
Contactperson for the course
dr. J.H.F. de Baaij
Other course modules lecturer
Examiner
dr. J.H.F. de Baaij
Other course modules lecturer
Lecturer
prof. dr. R.J.M. Bindels
Other course modules lecturer
Academic year2019
Period
KW3-KW4  (03/02/2020 to 30/08/2020)
Starting block
KW3
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
At the end of the course the student can:
  • describe the normal structure and function of the kidney from the perspective of the homeostasis of the body
  • Describe by which processes the regulation of the ion and water homeostasis in the human body are realized
  • describe the proteins which play an important role in the regulation of ion and water homeostasis
  • understand how mutations in these proteins lead to diseases
  • understand the mechanisms by which therapies relieve these diseases
Content
The ability of animals and humans to live is directly related to the developed ability to independently control the availability of ions, water and nutrients from the environment, despite continuous changes. The kidney is the main organ for the regulation of ion and water homeostasis. For this, kidney epithelial cells integrate environmental signals resulting in activation or inactivation of specific channel and transporter proteins. Errors in such proteins lead to diseases such as hypertension, diabetes insipidus, and kidney stones.
Within the Radboud University Medical Center, high quality research in both basic and clinical aspects of these homeostatic regulations in health and disease is performed. In this course "pathophysiology of the kidney', the student becomes familiar with these processes ' from molecule to man’. The student will become acquainted with the occurrence and importance of the cellular membrane potential for the ability of the cell to transport ions and water, and the role of key- proteins herein. It will be clear to the students that this serves as the basis for the understanding of the mechanisms by which the different segments of the kidney maintain the regulation of the ion and water homeostasis of our body as an integrated whole.
With the obtained knowledge, the student will be able to understand diseases caused by mutations in proteins involved the regulation of the ion and water homeostasis, and understand the mechanism of therapies for these diseases. By means of lectures, self-study assignments, practical sessions and lecture responses, the above will be made clear. In addition, through group activities, the students will apply the material studied on clinical cases and try to explain and understand their disturbances in the homeostatic regulation.
Level

Presumed foreknowledge
Fundamental knowledge of the molecular biology, cell biology and animal physiology at Bachelor level
Test information
  • final exam Presence at work groups and practical sessions is mandatory to get access to the exam.
  • Specifics

    Test information
    • final exam
    Presence at work groups and practical sessions is mandatory to get access to the exam.

    Prerequisites
    Fundamental knowledge of the molecular biology, cell biology and animal physiology at Bachelor level

    Contact information
    Contact: Jeroen de Baaij 024-3617347 / jeroen.debaaij@radboudumc.nl

    Required materials
    Book
    Medical Physiology, Boron, WF, Boulpaep, E.L. Philadelphia: Saunders, A cellular and Molecular approach, 3e edition, 2016
    ISBN:9781455743773
    Reader
    Course book
    Book
    Functionele Histologie, Junqueira L.C., Carneiro J, Kelly R.O., Elsevier Gezondheidszorg Maarssen, 14e (of 15e edition),.
    ISBN:9789036810890

    Instructional modes
    (Computer)Lab course
    Attendance MandatoryYes

    Course occurrence

    Exam Q4

    Lecture

    Resit Exam Q4

    Response course

    Working group
    Attendance MandatoryYes

    Zelfstudie

    Tests
    Exam
    Test weight1
    Test typeExam
    OpportunitiesBlock KW3, Block KW4