NWI-BM004C
Apoptosis
Course infoSchedule
Course moduleNWI-BM004C
Credits (ECTS)3
CategoryMA (Master)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
Lecturer(s)
Coordinator
dr. W.C. Boelens
Other course modules lecturer
Lecturer
dr. W.C. Boelens
Other course modules lecturer
Contactperson for the course
dr. W.C. Boelens
Other course modules lecturer
Examiner
dr. W.C. Boelens
Other course modules lecturer
Academic year2019
Period
KW2  (04/11/2019 to 02/02/2020)
Starting block
KW2
Course mode
full-time
RemarksAcademic year 20/21 will be the last time this course is given
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
After completing the course you are able to:
  • evaluate the most relevant forms of cell death involved in physiological and pathological processes
  • explain in an accurate manner how the different types of cell deaths are regulated
  • explain in an accurate manner the involvement of cell death in the proper functioning of the immune system
  • explain in an accurate manner the involvement of cell death in avoiding the development of cancer
  • explain in an accurate manner how viruses regulate cell death for their own benefit
  • explain in an accurate manner the working mechanisms of drugs that regulate cell death
Content
Apoptosis is a form of programmed cell death that is meant to kill a cell clean and neatly. The process was neglected for a very long time, but its importance is now generally accepted. Apoptosis, and also other forms of cell death, play a crucial role in different aspects of life, such as embryonic development, tissue homeostasis and regulation of the immune response. Deregulation of cell death processes can lead to the development of autoimmune diseases, cancer, viral infections and many other diseases. The improved understanding of cell death processes has helped to develop new drugs to tread these kinds of diseases.
The course content is centered around the following themes:
  • Molecular aspects of Apoptosis, Necrosis and other forms of Cell Death
  • Induction of cell death under all kinds of stress conditions
Level

Presumed foreknowledge
Biochemistry and Molecular Biology II (BMB-II; NWI-BB017C)
Test information
Written exam.
Specifics
contact: Dr. W.C. Boelens, phone (024-36) 16753, e-mail: w.boelens@ncmls.ru.nl
Additional comments
contact: Dr. W.C. Boelens, phone (024-36) 16753, e-mail: w.boelens@ncmls.ru.nl

Topics
Aspects that will be discussed are:

• different forms of cell death
• signals that induce cell death
• how death cells are cleared
• detection of death cells
• relationship between apoptosis and immunity
• how viruses deal with apoptosis
• role of apoptosis in tumor development
• function of reactive oxygen species
• development of pro- and anti-apoptotic drugs

Test information
Written exam.

Prerequisites
Biochemistry and Molecular Biology II (BMB-II; NWI-BB017C)

Required materials
Handouts
Hand-outs, distributed via brightspace.

Instructional modes
Course occurrence

Lecture

Zelfstudie
Attendance MandatoryYes

Tests
Exam
Test weight1
Test typeExam
OpportunitiesBlock KW2, Block KW3