NWI-BM024D
Course on Laboratory Animal Sciences
Course infoSchedule
Course moduleNWI-BM024D
Credits (ECTS)3
CategoryMA (Master)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
Lecturer(s)
Coordinator
dr. ir. P.P.A.M. Leenaars
Other course modules lecturer
Lecturer
dr. ir. P.P.A.M. Leenaars
Other course modules lecturer
Contactperson for the course
dr. ir. P.P.A.M. Leenaars
Other course modules lecturer
Academic year2017
Period
KW1  (04/09/2017 to 12/11/2017)
Starting block
KW1/  KW2/  KW3
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
The student:
  1. is familiar with legislation concerning the use of laboratory animals.
  2. knows about basic principles, which guide towards the ethical judgement of animal experiments.
  3. has knowledge of the major anatomical and physiological characteristics of the commonly used laboratory animal species, with respect to the choice of the proper animal model.
  4. has knowledge of the requirements of laboratory animals with respect to housing, nutrition and care. Knows about safety aspects and occupational health when working with laboratory animals. has knowledge of the importance of hygienic measures and barrier systems.
  5. possesses the necessary knowledge for responsible animal handling and also obtained some practical experience in this respect; has taken note of the different methods for the collection of body fluids.
  6. has knowledge of the impact of diseases in laboratory animals on the experimental approach and knows about possible health monitoring.
  7. possesses the knowledge to recognise pain as well as discomfort in laboratory animals and to define humane endpoints.
  8. has knowledge of the most important methods of anaesthesia, analgesia and euthanasia, which can be used in various laboratory animal species.
  9. possesses the knowledge to define and apply humane endpoints.
  10. has insight into the possibilities and limitations of alternative techniques.
  11. knows the possibilities that statistics offer to optimise the use of laboratory animals. Knows about the specific demands that are necessary for a correct preparation and performance of animal experimental techniques and research. Has knowledge of the possible impact of environmental and procedural factors on experimental results. Has knowledge on information systems to search for alternatives; has knowledge on methods of synthesis of evidence like systematic reviews and meta-analysis.
  12. has taken note of the different methods for the collection of body fluids. Has taken note of a number of other frequently used experimental techniques (amongst others cannulation, insertion of catheters).
  13. Specific knowledge for mice and rats on items:
    • has knowledge of the anatomical and physiological characteristics of mice and rats with respect to the choice of the proper animal model.
    • has knowledge of the requirements of mice and rats with respect to housing, nutrition and care.
    • possesses the necessary knowledge for responsible handling of mice and rats and also obtained some practical experience in this respect; has taken note of the different methods for the collection of body fluids.
    • possesses the knowledge to recognise pain as well as discomfort in mice and rats
    • has knowledge of the most important methods of anaesthesia, analgesia and euthanasia, which can be used in mice and rats.
    • possesses the knowledge to define and apply humane endpoints in mice and rats.
    • has taken note of the different methods for the collection of body fluids from mice and rats. Has taken note of a number of other frequently used experimental techniques (amongst others cannulation, insertion of catheters) in mice and rats.
Learning outcomes in accordance with the EC Training and Education document relating to Directive EU/2010/63, http://ec.europa.eu/environment/chemicals/lab_animals/pdf/Endorsed_E-T.pdf
Content
The objective of the course on laboratory animal science is to present basic facts and principles that are essential for the humane use and care of laboratory animals and for the quality of research. The course will focus on the responsible and appropriate use of animals in scientific experiments in which alternatives (refinement, reduction, replacement) play an essential role. The course has the aim to gain knowledge and insight into the design of an animal experiment in a scientific and ethically justified manner, taken into account the 3Rs principles.
The program of the course on laboratory animal science comprises the requirements of the Dutch 'Wet op de dierproeven' (Experiments on Animals Act).  The Laboratory Animal Science course includes an introductory course as well as a species-specific course on mice and rats. The certificate of completion of the course together with an academic master degree in biomedical sciences will lead to a legal recognition to design animal experiments in the Netherlands. The Laboratory Animal Science course referred to in annex 6 belonging to Article 5 of the Ministerial Order on Animal Experiments 2014 (Dierproevenregeling 2014), and meets the requirements referred to in article 23.2(b) and annex V belonging to Article 23.3 of directive 2010/63/EU on the protection of animals used for scientific purposes (22 September 2010) of the European Parliament and of the Council.
Literature
The core textbook in Dutch (less expensive than English copy):

• Zutphen, L.F.M. van, V. Baumans & F.Ohl, Handboek Proefdierkunde. proefdieren, dierproeven, alternatieven en ethiek, 2009, Uitgeverij Elsevier gezondheidszorg, Maarssen, vijfde druk. ISBN 9789035229815
The core textbook in English:

• Zutphen, L.F.M. van, Baumans, V. & Beynen, A.C. (eds.), Principles of Laboratory Animal Science: A contribution to the humane use and care of animals and the quality of experimental results, 2001, Elsevier Science Publishers, Amsterdam, 2nd (revised) edition. ISBN-13: 978-0444506122.
* A digital module guide will be available.

Teaching formats
Lectures, interactive lectures, practicals, demonstrations, individual and group assignments. Several (external) guest lecturers will appear.

Additional comments
The course is not an obligatory part of the study Biology. The Course on Laboratory Animal Science is organised by the Central Animal Laboratory (CDL) and lectured in English.The course is scheduled 4 times a year and is a two weeks full time course. For dates and application forms see the website of the CDL.
https://www.radboudumc.nl/en/education/courses/course-on-laboratory-animal-science-las
You can apply by sending the application form to: courseinlas.cdl@radboudumc.nl
In addition, FNWI students have to register via OSIRIS. Requests for further information may also be sent to: courseinlas.cdl@radboudumc.nl

Topics
Topics are mentioned in the learning objectives.

Test information
The examination is based on a written exam and the group assignment. The examination is scheduled on the Friday of the second week of the course.

Prerequisites
The course is only open for master students who have at least 500 study hours in basic biology. At least 200 study hours anatomy/zoology and 200 study hours animal physiology should be part of this 500 study hours in basic biology. For Molecular Life Science (MLW) students this means:
• part of the first year biology course "Ontwikkeling en evolutie in de bouwplannen van dieren" (BP004B). For detailed information contact the coordinator of this course: dr J.R. Metz (j.metz@science.ru.nl)
• one or both of the following courses from the bachelor of biology: "Endocrinologie" (BB048B) or "Adaptatiefysiologie" (BB020B)
• one or both of the following capita selecta from the master of biology "Endocrinology" (BM048B) or "Adaptation Physiology" (BM010B)

Contact information
Marlies.Leenaars@radboudumc.nl

Required materials
Book
Zutphen, L.F.M. van, Baumans, V. & Beynen, A.C. (eds.), Principles of Laboratory Animal Science: A contribution to the humane use and care of animals and the quality of experimental results, 2001, Elsevier Science Publishers, Amsterdam, 2nd (revised)
Blackboard
A digital module guide will be available.

Instructional modes
Course
Attendance MandatoryYes

Lab course
Attendance MandatoryYes

Lecture
Attendance MandatoryYes

Opdrachten
Attendance MandatoryYes

Tests
Tentamen
Test weight1
OpportunitiesBlock KW1