NWI-BM064
Protein Dynamics and Networks
Course infoSchedule
Course moduleNWI-BM064
Credits (ECTS)3
CategoryMA (Master)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
Lecturer(s)
Lecturer
dr. C. Furlan
Other course modules lecturer
Lecturer
dr. M.M. Makowski
Other course modules lecturer
Lecturer
prof. dr. M. Vermeulen
Other course modules lecturer
Coordinator
prof. dr. M. Vermeulen
Other course modules lecturer
Contactperson for the course
prof. dr. M. Vermeulen
Other course modules lecturer
Academic year2017
Period
KW1  (04/09/2017 to 12/11/2017)
Starting block
KW1
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
At the end of the course you can:
·         Understand the basic principles of quantitative mass spectrometry (MS)-based proteomics technology and apply this knowledge to address questions in data-driven research (P1, P2, P5).
·         Apply existing software programs to analyze quantitative mass spectrometry data and interpret obtained results in the context of published literature (P3).
·         Formulate insightful questions based on an evaluation of ongoing research from guest speakers, thus demonstrating acquired knowledge in state-of-the-art proteomics research  (A1).
·         Acknowledge the complementary nature of proteomics and (epi-)genomics approaches and design simple approaches to study relevant questions on a system-wide level (P5)
 
Content
During the last decade, mass spectrometry-based proteomics emerged as a powerul tool in biology. This course aims to present the basic concepts of this technology and some of its applications. Special emphasis will be given to applications in health and disease, such as development and cancer. The course will consist of lectures, seminars from external academic and industrial experts as well as a practical component.
Teaching formats

• 12 hours guided group project work
• 2 hours excursion
• 15 hours lecture
• 10 hours laboratory course
• 3 hours question session
• 2 hours tutor session
• 40 hours individual study period
Extra information teaching methods: lectures, pracitcal, guest lectures, study current literature, Q+A session, excursion

Topics
• Basic principles and workflows of quantitative mass spectrometry
• Signaling pathways / post-translational modifications
• Protein-protein and protein-DNA interactions
• Proteomics in epigenetics research
• Protein (complex) structures
• Clinical proteomics
• Applied mass spectrometry in industry
• Integrative proteomics for systems biology

Test information
written exam (70%), practical report (20%), Q+A session (10%)

Prerequisites
Knowledge of the principles of genome architecture and gene regulation (NWI-BB064B (Functional Genomics I) or Lodish 7th edition chpt 5-7 or equivalent)

Instructional modes
Course
Attendance MandatoryYes

Lab course
Attendance MandatoryYes

Lecture

Project
Attendance MandatoryYes

Response course

Tutorial
Attendance MandatoryYes

Zelfstudie

Tests
Tentamen
Test weight1
OpportunitiesBlock KW1, Block KW2