NWI-BM064
Protein Dynamics and Networks
Course infoSchedule
Course moduleNWI-BM064
Credits (ECTS)3
CategoryMA (Master)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
Lecturer(s)
Lecturer
dr. K.W. Mulder
Other course modules lecturer
Examiner
prof. dr. M. Vermeulen
Other course modules lecturer
Lecturer
prof. dr. M. Vermeulen
Other course modules lecturer
Coordinator
prof. dr. M. Vermeulen
Other course modules lecturer
Contactperson for the course
prof. dr. M. Vermeulen
Other course modules lecturer
Academic year2019
Period
KW1  (02/09/2019 to 03/11/2019)
Starting block
KW1
Course mode
full-time
Remarks20/21 last year for this 3EC course. From 21/22 combined with BM062 to a 6EC course
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
At the end of the course you can:
·         Understand the basic principles of quantitative mass spectrometry (MS)-based proteomics technology and apply this knowledge to address questions in data-driven research (P1, P2, P5).
·         Apply existing software programs to analyze quantitative mass spectrometry data and interpret obtained results in the context of published literature (P3).
·         Acknowledge the complementary nature of proteomics and (epi-)genomics approaches and design simple approaches to study relevant questions on a system-wide level (P5)
 
Content
During the last decade, mass spectrometry-based proteomics emerged as a powerul tool in biology. This course aims to present the basic concepts of this technology and some of its applications. Special emphasis will be given to applications in health and disease. The course consists of lectures and also contains a computer exercise.
Level

Presumed foreknowledge
Knowledge of the principles of genome architecture and gene regulation (NWI-BB064B (Functional Genomics I) or Lodish 7th edition chpt 5-7 or equivalent)
Test information
written exam (70%), practical report (20%), Q+A session (10%)
Specifics
In 2020/2021 this 3EC course will be given for the last time. From 2021/2022 on the course will be combined with BM062 to one 6EC course.
Additional comments
In 2020/2021 this 3EC course will be given for the last time. From 2021/2022 on the course will be combined with BM062 to one 6EC course.

Topics
• Basic principles and workflows of quantitative mass spectrometry
• Signaling pathways / post-translational modifications
• Protein-protein and protein-DNA interactions
• Proteomics in epigenetics research
• Protein (complex) structures
• Clinical proteomics
• Applied mass spectrometry in industry
• Integrative proteomics for systems biology

Test information
written exam (70%), practical report (20%), Q+A session (10%)

Prerequisites
Knowledge of the principles of genome architecture and gene regulation (NWI-BB064B (Functional Genomics I) or Lodish 7th edition chpt 5-7 or equivalent)

Instructional modes
Course
Attendance MandatoryYes

Lecture

Response course

Tutorial
Attendance MandatoryYes

Zelfstudie

Tests
Exam
Test weight4
Test typeExam
OpportunitiesBlock KW1, Block KW2

Assignment
Test weight1
Test typeAssignment
OpportunitiesBlock KW1