NWI-BM073
Trends in Stem Cell Biology
Course infoSchedule
Course moduleNWI-BM073
Credits (ECTS)3
CategoryMA (Master)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
Lecturer(s)
Coordinator
dr. H. Zhou
Other course modules lecturer
Lecturer
dr. H. Zhou
Other course modules lecturer
Contactperson for the course
dr. H. Zhou
Other course modules lecturer
Academic year2017
Period
KW1  (04/09/2017 to 12/11/2017)
Starting block
KW1
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
At the end of this course, you are able to
  • explain in general terms the basic definitions of different types of mammalian stem cells in terms of potency and self-renewal as described in literature, and their difference to differentiated cells.
  • evaluate experimental data discussed in the lecture or from similar experiments regarding the (epigenetic) regulation in pluripotent stem cells and reprogramming.
  • demonstrate the importance of stem cells in biomedical research for understanding development and disease based on the unique properties of stem cells.
  • design experiments to identify mechanisms important for properties of different stem cells and relevant diseases using the molecular tools and technologies as discussed in the lectures.
  • illustrate how various types of stem cells currently used in the clinic, in clinical trials and/or in clinical studies.
  • reflect on the most relevant ethical issues of using stem cells for research and therapies, and formulate and defend your opinions with arguments by means of oral presentation and scientific discussion.
Content
Medical Epigenomics
Hendrik Marks: Molecular Biology, Radboud University, h.marks@ncmls.ru.nl
Introduction of the course, Epigenetics and pluripotency in mouse stem cells

Jo Huiqing Zhou: Molecular Developmental Biology, Radboud University, j.zhou@science.ru.nl
Reprogramming to induced pluripotent stem cells

Neurobiology
Koen Kole: Neurophysiology, Radboud University, k.kole@neurophysiology.nl
Neural stem cells, neurogenesis, and spinal cord injury

Nael Nadif Kasri: Cognitive Neuroscience, Radboudumc, Nael.NadifKasri@radboudumc.nl
Stem cells in neurobiology 

Human Biology
Harry Dolstra: Laboratory Medicine, Radboudumc, Harry.Dolstra@radboudumc.nl
Haematopoietic stem cells in transplantation

Ellen van den Bogaard: Dermatology, RAdboudumc, Ellen.vandenBogaard@radboudumc.nl
Epidermal keratinocytes in treatment
 
Guest Lecturer, Ethics
Elisa Garcia-Gonzalez: IQ healthcare, Radboudumc, Elisa.GarciaGonzalez@radboudumc.nl
Ethics in stem cell research 


Discussion on ethical issues (supervision: Jo Zhou/Hendrik Marks)

 
Recommended materials
Blackboard
Attending lectures is highly recommended for this course, as this is a literature review course and no textbook is available. Students are asked to study the literature provided by the lecturers. Content of the lectures are available on Blackboard.

Instructional modes
Course
Attendance MandatoryYes

General
Seven lectures: 2x45-minute lecture per week, except one day of ethical group discussion

Preparation of meetings
Each lecture except the lecture on ethics will explain basic concepts and discuss ONE key paper in the field. Students are asked to read the paper before the lecture.

Contribution to group work
Basic concepts of ethical issues and ethical topics relevant to stem cell biology will be discussed. A lecture on ethical issues will be given by Dr. Elisa Garcia-Gonzalez to introduce basic concepts of ethical issues. Subsequently group discussion of given ethical topics will be performed by students followed by presentations to summarize the discussions.

Remark
This course is composed of seven lectures and one obligatory session of ethical discussion.

Lecture

General
Two lectures for each of the specialization, Human Biology, Medical Epigenomics or Neuroscience; plus one lecture on ethical issues

Preparation of meetings
Students are asked to read the paper before the lecture.

Remark
2x45 minutes per lecture. Totally 7 lectures.

Tutorial
Attendance MandatoryYes

General
Students will be grouped into several groups working with different ethical issue topics.

Preparation of meetings
Students will be grouped into several groups working with different ethical issue topics. Students are asked to discuss their topics with group members and make presentations during group discussion session.

Contribution to group work
Basic concepts of ethical issues and ethical topics relevant to stem cell biology will be discussed. A lecture on ethical issues will be given by Dr. Elisa Garcia-Gonzalez to introduce basic concepts of ethical issues. Subsequently group discussion of given ethical topics will be performed by students followed by presentations to summarize the discussions.

Tests
Tentamen
Test weight1
OpportunitiesBlock KW1, Block KW2