Trends in Stem Cell Biology
Course infoSchedule
Course moduleNWI-BM073
Credits (ECTS)3
Category03 (Advanced)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
PreviousNext 4
prof. dr. E.H.J. van den Bogaard
Other course modules lecturer
dr. L. Consoli
Other course modules lecturer
dr. H. Marks
Other course modules lecturer
prof. dr. E.J.M. Storkebaum
Other course modules lecturer
dr. A.B. van der Waart
Other course modules lecturer
Academic year2020
KW1  (31/08/2020 to 01/11/2020)
Starting block
Course mode
Registration using OSIRISYes
Course open to students from other facultiesYes
Waiting listNo
Placement procedure-
At the end of this course, you are able to
  • explain in general terms the basic definitions of different types of mammalian stem cells in terms of potency and self-renewal as described in literature, and their difference to differentiated cells.
  • evaluate experimental data discussed in the lecture or from similar experiments regarding the (epigenetic) regulation in pluripotent stem cells and reprogramming.
  • explain the importance of stem cells in biomedical research for understanding development and disease based on the unique properties of stem cells.
  • explain how stem cells and their derived cells can serve as cellular models for studying diseases, and analyze and interpret experimental data obtained from these studies.
  • design experiments to identify mechanisms important for properties of different stem cells and relevant diseases using the molecular tools and technologies as discussed in the lectures.
  • illustrate how various types of stem cells are currently used in the clinic, in clinical trials and/or in clinical studies.
  • reflect on the most relevant ethical issues of using stem cells for research and therapies, and formulate and defend your opinions with arguments by means of oral presentation and scientific discussion.
General information about the course and Guest Lecturer, Ethics
Luca Consoli: Institute of science in society, Radboud Univeristy, l.consoli@science.ru.nl
Jo Huiqing Zhou (course coordinator), Molecular Developmental Biology, Radboud University, j.zhou@science.ru.nl

Hendrik Marks: Molecular Biology, Radboud University, h.marks@science.ru.nl
Medical Epigenomics
Jo Huiqing Zhou: Molecular Developmental Biology, Radboud University, j.zhou@science.ru.nl
Erik Storkebaum: Molecular Neurobiology, Radboud University, e.storkebaum@science.ru.nl
Human Biology
Anniek van der Waart: Laboratory Medicine, Radboudumc, Anniek.vanderwaart@radboudumc.nl
Ellen van den Bogaard: Dermatology, Radboudumc, Ellen.vandenBogaard@radboudumc.nl

Instructional Modes
  • Lecture
  • Tutorial, ethical issue discussion
Master first year
Presumed foreknowledge
General basic knowledge in biology and biochemistry. Basic stem cell biology will be a plus.
Test information
The final grade is based upon 2 tests: Exam: minimum of 5.0 which counts for 80% Ethics component: minimum of 5.0 which counts for 20%

Recommended materials
Learning Management System (Brigthspace)
Attending lectures is highly recommended for this course, as this is a literature review course and no textbook is available. Students are asked to study the literature provided by the lecturers. Content of the lectures are available on Btightspace.

Instructional modes
Attendance MandatoryYes

Seven lectures: 2x45-minute lecture per week, except one day of ethical group discussion

Preparation of meetings
Each lecture except the lecture on ethics will explain basic concepts and discuss ONE key paper in the field. Students are asked to read the paper before the lecture.

Contribution to group work
Basic concepts of ethical issues and ethical topics relevant to stem cell biology will be discussed. A lecture on ethical issues will be given by Dr. Elisa Garcia-Gonzalez to introduce basic concepts of ethical issues. Subsequently group discussion of given ethical topics will be performed by students followed by presentations to summarize the discussions.

This course is composed of seven lectures and one obligatory session of ethical discussion.

Digital Exam
Test weight4
Test typeDigital exam with CIRRUS
OpportunitiesBlock KW1, Block KW2

Ethics (presentation and essay)
Test weight1
Test typePresentation
OpportunitiesBlock KW1