NWI-BM077
Genomics
Course infoSchedule
Course moduleNWI-BM077
Credits (ECTS)3
Category03 (Advanced)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
Lecturer(s)
Coordinator
prof. dr. I. Rieu
Other course modules lecturer
Lecturer
prof. dr. I. Rieu
Other course modules lecturer
Contactperson for the course
prof. dr. I. Rieu
Other course modules lecturer
Examiner
prof. dr. I. Rieu
Other course modules lecturer
Academic year2019
Period
KW1  (02/09/2019 to 03/11/2019)
Starting block
KW1
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
After following this course, you can:
  1. easily navigate in genomics data; you know where and how to find the data you need
  2. get up-to-date information about genes of interest
  3. perform standard bioinformatics analyses of genome-wide data with online-available tools
  4. design the algorithms for non-standard bioinformatics analyses of genomics data
  5. perform phylogenetic analysis using sequence information
Content
With the development of high-throughput genome-scale technologies, scientists get unprecedented access to data on the structure, function and evolution of genomes. In this course, we will overview the recent developments in genomics and train the bioinformatics tools and software used to gain insight in organismal physiology and evolution. We will start from the analysis of whole-genome datasets to identify the candidate genes for further bioinformatics analysis and to formulate testable hypothesis. Then we will screen the available genomics data to get new information about the candidate genes, e.g. where they express, with which conditions they associate, if their coding and non-coding regions possess any signals etc. Finally, we will perform phylogenetic analysis to understand evolution of the candidate genes and the evolutionary relationships of species.
Level
Master
Presumed foreknowledge
BSc level knowledge of molecular biology
Test information
In-course assignments, exam
Specifics

Topics
• Generation of sequence data, assembly and basic annotation
• Databases in genomics
• Pairwise alignment
• Molecular evolution
• Phylogenetic analysis
• Signals in biological sequences
• Transcriptomics
• Proteomics
• Gene Networks

Levels
Master

Test information
In-course assignments, exam

Prerequisites
BSc level knowledge of molecular biology

Contact information
Ivo Rieu (i.rieu@science.ru.nl)

Recommended materials
Handouts
All study materials will be made available during the course.

Instructional modes
Assignment

Remark
4 h

Lecture

Remark
16 h

Practical computer training
Attendance MandatoryYes

Remark
26 h

Project

Remark
16 h

Response course

Remark
2 h

Self study time

Remark
6 h

Tests
Exam
Test weight1
Test typeExam
OpportunitiesBlock KW1, Block KW2

Assignment
Test weight1
Test typeAssignment
OpportunitiesBlock KW1, Block KW2