NWI-BM079
Kidney Physiology: From Bench to Bedside
Course infoSchedule
Course moduleNWI-BM079
Credits (ECTS)3
Category04 (Expert)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
Lecturer(s)
PreviousNext 2
Coordinator
dr. J.H.F. de Baaij
Other course modules lecturer
Examiner
dr. J.H.F. de Baaij
Other course modules lecturer
Contactperson for the course
dr. J.H.F. de Baaij
Other course modules lecturer
Lecturer
dr. J.H.F. de Baaij
Other course modules lecturer
Lecturer
dr. J. Jansen
Other course modules lecturer
Academic year2023
Period
KW2  (06/11/2023 to 28/01/2024)
Starting block
KW2
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
After completing the course, the student should be able:
1. to explain in his/her own words the basic physiological mechanisms of volume regulation, pH homeostasis and osmoregulation by the kidney,
2. to select the appropriate advanced research technique to answer a scientific question in renal research based on strengths and limitation analysis and
3. to design a research strategy to solve a genetic syndrome of disturbed renal ion transport using clinical and fundamental research approaches.
Content
1) Basic physiology of the kidney
In this course you will get insight in the anatomy of the kidney. You will go on a tour along the nephron and learn about the function of the different kidney segments. The role of the kidneys in urine concentration, blood pressure regulation, acid-base homeostasis and mineral metabolism will be discussed. You will acquire insight into basic renal physiology coupled to various kidney disorders and medicines that influence volume and osmoregulation. 
2) From ion channel to kidney disease
The resorption process of ions and minerals is controlled by transport proteins and ion channels. Several hereditary renal syndromes have been described over the past 50 years and many of these renal diseases have been based on mutations in renal ion channels. You will follow the complete trajectory of identification of new genetic diseases: from genetic diagnosis, to functional research and treatment design.

3) State-of-the-art kidney research
In the final part of the course, we will focus on the current advances in renal research. Thanks to recent technical improvements in biomedical research, we can now unravel the structure and functional of ion channels using advanced patch clamp techniques, crystallography and cryo-EM. Therefore, we can understand the molecular mechanisms responsible for the resorption process and use these knowledge and research methods to develop targets for new medicines.
 
Relevance
The kidneys take care of the purification of our blood but are also responsible for the maintenance of the water and electrolyte balance. In this module you will learn about the anatomy, physiology and pathophysiology of the kidneys and about the most recent advances in (kidney) research. The competencies that are trained in this course are useful for a broad range of medical researchers and policy makers.
 
This course is relevant for students interested in human biology. This course:
- increases your knowledge about renal physiology and pathology;
- introduces state-of-the-art techniques that are commonly used in medical research;
- focuses on translational research integrating fundamental and clinical research findings;
- trains to design novel research strategies to tackle clinical problems.

Instructional Modes
  • Lecture
  • Working Groups
  • Response course
  • Self-study
Level
Master, advanced
Presumed foreknowledge
Basic knowledge of kidney physiology
Test information
Written exam (75%) and presentation and report (25%). 2 Assignments (required to pass satisfactory)
Specifics

Required materials
Book
Boron & Boulpaep - Medical Physiology 3rd edition (accessible via UBN-website)
Reader
Course guide (available via Brighspace)
Literature
Selected scientific literature (available via Brighspace)

Instructional modes
Course
Attendance MandatoryYes

Lab course
Attendance MandatoryYes

Practical computer training
Attendance MandatoryYes

Project
Attendance MandatoryYes

Tests
Exam
Test weight3
Test typeExam
OpportunitiesBlock KW2, Block KW3

Presentations and Report
Test weight1
Test typePresentation
OpportunitiesBlock KW2