 | | | | | Course module | | NWI-BP007C | | Category | | 01 (Introduction) | | Language of instruction | | English | | Offered by | | Radboud University; Faculty of Science; BioWetenschappen; | | Lecturer(s) | | | | | Previous | | | | Next 2 |
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| | Academic year | | 2019 | | | Period | | | KW2 | (04/11/2019 to 02/02/2020) |
| | Starting block | | | KW2 | |
| | Course mode | | | full-time | |
| | Remarks | | - | | Registration using OSIRIS | | Yes | | Course open to students from other faculties | | Yes | | Pre-registration | | No | | Waiting list | | No | | Placement procedure | | - |
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Course objectives
This course is to give the first-year bachelor students an introduction of basic concepts of biochemistry and cell biology in animal cells.
Learning goals
Upon completing this course, the student is able to:
- Understand and analyse how biological macromolecules in the cell are constructed and how they function.
- Understand how certain nutrients are taken up and via which metabolic pathway these nutrients are degraded for energy gain.
- Understand how the above processes functionally interact and how they are involved in human biology and diseases, particularly the onset and progression of cancer.
- Apply the biochemical and cell biological knowledge to describe the physiological function of molecular components and regulators of the cell biological processes mentioned above.
- Work in a team/pairs, able to divide the tasks and share gained results with the team.
- Report their performed research in the form of a scientific report
Specific learning goals for the content of the course
Upon completing this course, the student is able to:
- Understand and describe amino acid types and properties.
- Understand and describe the primary, secondary, tertiary and quaternary structure of proteins.
- Describe the principles of experimental methods that are used to determine properties of proteins, such as molecular mass or isoelectric point, and methods that are used to separate and purify proteins.
- Analyze the most important parameters for enzyme kinetics and the role of different types of inhibitors.
- Understand and describe the properties of fatty acids, cholesterol and phospholipids and their role in the composition and behaviour of cellular membranes.
- Understand and describe how sugar structures originate and give rise to functional polymers.
- Understand the role that Gibbs energy plays in chemical reactions, and based on this, determine whether single or coupled chemical reactions can proceed spontaneously.
- Understand and describe key aspects of cell communication and cell signal transduction through membrane receptors and secondary messengers.
- Understand and describe key aspects of regulation and function of the cytoskeleton in cell morphology, intracellular transport, cell migration and mitosis.
- Understand and describe key aspects of integration of cells in tissues, and the functions of cell adhesion and extracellular matrix proteins.
- Understand and describe basic concepts of cell cycle regulation including processes during the various stages of the cell cycle and how polypeptide growth factors can control the cell cycle.
- Understand the evolutionary differences between cellular proto-oncogenes, activated cellular oncogenes and viral oncogenes, and understand how activated cellular oncogenes and viral oncogenes give normal cells an autonomous growth behavior and how dominant activating mutations in cellular proto-oncogenes may lead to tumour growth.
- Understand the differences between normal cells, tumour cells and stem cells.
Course module 'Cytology' (0 EC) is part of the courses in this quarter:
After completion of the Versatest module ‘Cytology’ you will have refreshed your memory, and high-school knowledge, of the animal cell. You can recognise, name, and explain the function of cell organelles and of key cellular processes.
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Topics Cellular biochemistry
- Interactions in aqueous systems and amino acids
- Protein structure, folding and processing of proteins
- Protein detection and purification
- Cytoskeleton and extracellular matrix
- Enzymes: working mechanisms, kinetics and inhibitors
- Catabolism of amino acids and fatty acids/lipids
- Principles of bioenergetics
- Carbohydrates & Glycoconjugates
- Receptors and signal transduction 1&2
- Tumor suppressor genes and oncogenes
- Cell cycle regulation in normal cells, stem cells and tumor cells
Content and Topics Course module 'Cytology'
Content
The Versatest module ‘Cytology’ prepares you for the courses in Q2 and Q3, among others ‘Histology’ (BP006B). We will address morphology and functions of key cellular components incl. the cytoplasm, cell membrane, nucleus, mitochondrion, ribosome, Golgi-apparatus, Rough and Smooth Endoplasmic Reticulum (RER/SER), Lysosome, Peroxisome, Cytoskeleton, Microtubules, Cilia, Centriole, (Micro)filament. Key cellular processes incl. active and passive transport, endo- and exocytosis, hetero- and autophagy, are also addressed.
The Versatest module ‘Cytology’ will be introduced in a short lecture (~30 min), after which you can follow the module online. A formative test is included, and can be completed in your own time.
Topics
Cytology of cytoplasm, cell membrane, nucleus, mitochondrion, ribosome, Golgi-apparatus, rough and smooth Endoplasmic Reticulum, Lysosome, Peroxisome, Cytoskeleton, Microtubules, Cilia, Centriole, (Micro)filament.
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| | | Dutch high school vwo-level, chemistry and biology knowledge required
Prerequisites course module Cytology:
High school level cytology and animal cell biology. |
| | The final grade consists of 80% the exam score and 20% the lab practical score and must be 5.5 to pass the course. Please note that a minimum score of 5.5 for both the written exam and the lab practical is needed to pass the exam.
Course module Cytology:
The Versatest module ‘Cytology’ will be introduced in a short lecture (~30 min), after which you can follow the module online. A formative test is included, and can be completed in your own time. (Multiple Choice and point-and-click questions via Versatest). |
| | Additional comments Cellular Biochemistry
Students are asked to attend compulsory learning activities: (content) tutorials, the computer practical and the lab practical and related feedback sessions on the report. All learning activities are complementary to lectures, because not all course content can be elaborated in the lectures! Tutorials and the computer practical rehearse lectures and give you a chance to practice using the content. The lab practical gives you an opportunity to execute experiments using the content of one of the topics and to understand the topic in depth. All these learning activities together synergize to cover the matter you need to learn for this course.
The course is based on two books:
1. “Lehninger Principles of Biochemistry” (7th edition), Authors, David L Nelson, Michael Cox, ISBN 9781319150877
2. “Molecular Cell Biology” (8th Edition), Authors: Arnold Berk, Chris A. Kaiser, Harvey Lodish, Angelika Amon, Hidde Ploegh, Anthony Bretscher, Monty Krieger, Kelsey C. Martin, ISBN 9781464187445
The assignments for the tutorials, computer labs and lab courses can be found in the manual (available via Brightspace). Please note that the files in Brightspace will be updated whenever new information is available to students. The Powerpoint slides of the lectures can be downloaded in pdf format via Blackboard during the course.
The lectures this academic year will be recorded on video. You will find the recordings on Brightspace, in the folder “Weblectures”.
Required Materials for the course module Cytology (0 EC):
Mescher (A.L.): Junqueira’s Basic Histology, Text and Atlas, 14th or 15th ed. This book is also intensively used in the ‘Histology’ course (BP006B).
Instructional modes for Cytology course
~30 min introductory lecture
~1 h 15 min Versatest (computer) practical |
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Additional comments Cellular Biochemistry
Students are asked to attend compulsory learning activities: (content) tutorials, the computer practical and the lab practical and related feedback sessions on the report. All learning activities are complementary to lectures, because not all course content can be elaborated in the lectures! Tutorials and the computer practical rehearse lectures and give you a chance to practice using the content. The lab practical gives you an opportunity to execute experiments using the content of one of the topics and to understand the topic in depth. All these learning activities together synergize to cover the matter you need to learn for this course.
The course is based on two books:
1. “Lehninger Principles of Biochemistry” (7th edition), Authors, David L Nelson, Michael Cox, ISBN 9781319150877
2. “Molecular Cell Biology” (8th Edition), Authors: Arnold Berk, Chris A. Kaiser, Harvey Lodish, Angelika Amon, Hidde Ploegh, Anthony Bretscher, Monty Krieger, Kelsey C. Martin, ISBN 9781464187445
The assignments for the tutorials, computer labs and lab courses can be found in the manual (available via Brightspace). Please note that the files in Brightspace will be updated whenever new information is available to students. The Powerpoint slides of the lectures can be downloaded in pdf format via Blackboard during the course.
The lectures this academic year will be recorded on video. You will find the recordings on Brightspace, in the folder “Weblectures”.
Required Materials for the course module Cytology (0 EC):
Mescher (A.L.): Junqueira’s Basic Histology, Text and Atlas, 14th or 15th ed. This book is also intensively used in the ‘Histology’ course (BP006B).
Instructional modes for Cytology course
~30 min introductory lecture
~1 h 15 min Versatest (computer) practical |
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The final grade consists of 80% the exam score and 20% the lab practical score and must be 5.5 to pass the course. Please note that a minimum score of 5.5 for both the written exam and the lab practical is needed to pass the exam.
Course module Cytology:
The Versatest module ‘Cytology’ will be introduced in a short lecture (~30 min), after which you can follow the module online. A formative test is included, and can be completed in your own time. (Multiple Choice and point-and-click questions via Versatest). |
Dutch high school vwo-level, chemistry and biology knowledge required
Prerequisites course module Cytology:
High school level cytology and animal cell biology. |
| | | Required materialsBook| “Lehninger Principles of Biochemistry” (7th edition), Authors, David L Nelson, Michael Cox, ISBN 9781319150877 |
| ISBN | : | | 9781319150877 |
| Title | : | | Lehninger Principles of Biochemistry |
| Author | : | | David L Nelson, Michael Cox |
| | Course guide | Course guide| Lecture slides, explanations about the lab courses and computer practical courses |
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Instructional modesCourse occurrence
| Lab course| Attendance Mandatory | | Yes |
| Lecture
| Response course
| Tutorial| Attendance Mandatory | | Yes |
| Zelfstudie
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TestsDigital Exam| Test weight | | 4 |
| Test type | | Digital exam with CIRRUS |
| Opportunities | | Block KW2, Block KW3 |
| Practical| Test weight | | 1 |
| Test type | | Lab course |
| Opportunities | | Block KW2 |
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