NWI-BP031
Genomics and Big Data
Course infoSchedule
Course moduleNWI-BP031
Credits (ECTS)6
Category01 (Introduction)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; BioWetenschappen;
Lecturer(s)
Contactperson for the course
dr. A. Minoda
Other course modules lecturer
Lecturer
dr. A. Minoda
Other course modules lecturer
Lecturer
dr. T. Yu
Other course modules lecturer
Examiner
dr. T. Yu
Other course modules lecturer
Coordinator
dr. T. Yu
Other course modules lecturer
Academic year2023
Period
KW3  (29/01/2024 to 07/04/2024)
Starting block
KW3
Course mode
full-time
RemarksStudents who want to follow this course as part of a premaster or minor, contact the premaster/minor student advisor
Registration using OSIRISYes
Course open to students from other facultiesNo
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims

This course consists of two main themes: genomics and data science. The learning outcomes are listed here, organized by the themes.

 A. Genomics

At the end of the course you can:

  1. describe the properties of eukaryotic genomes and explain the mechanisms involved in genome organization.
  2. describe the advantages and limitations of next-generation sequencing and list applications within different biological domains.
  3. list major genomic data sources and use them to search and retrieve relevant information to characterize nucleotide sequences.

 B. Data science

At the end of this course you can:

  1. describe the properties of well-formatted data and common problems with messy data and apply this knowledge to clean raw data sets to make them suitable for analysis.
  2. use R to summarize large datasets using descriptive statistics and effective visualizations, and interpret the results.
  3. compare and contrast hypothesis-driven and data-driven (exploratory) analysis and formulate a testable hypothesis for a specific data set
  4. describe the differences between parametric and non-parametric statistical tests, can choose and apply an appropriate test for specific hypothesis and can apply and interpret a correlation or linear regression analysis.
  5. explain the concept of multiple testing correction, apply corrections and interpret the results.
  6. define the concept of open data and describe issues, considerations and benefits involved in data sharing.
Content

Level

Presumed foreknowledge
Statistics 1
Test information
  • Exam, counts for 30%, minimum grade 5.0
  • Computer assignment, counts for 30%, minimum grade 5.0
  • Team-Based Learning, counts for 40%, minimum grade 5.0
Specifics
The group work in this course uses Team-Based Learning (TBL), an evidence-based collaborative learning strategy. It consists of the following steps: 1) students prepare material before class, 2) students complete and individual and a team-based "readiness assurance test" (iRAT and tRAT) 3) knowledge is applied and extended in application session during the group work.
Required materials
Handouts
Lecture slides and hand outs will be provided during the course and via Blackboard.
Websites
Various on-line material will be used throughout the course. Details will follow during the course and will be communicated via Blackboard.

Recommended materials
Book
The the book is mandatory, the printed version of the book is optional. An on-line version can be found free-of-charge here: https://serialmentor.com/dataviz/
ISBN:9781492031086
Title:Fundamentals of Data Visualization
Author:Claus Wilke
Publisher:O'Reilly Media, Inc, Usa
Edition:1
Costs:50.00
Book
While this book is mandatory, the printed version is optional. The book can be found on-line, free-of-charge here: http://web.stanford.edu/class/bios221/book/.
ISBN:9781108705295
Title:Modern Statistics for Modern Biology
Author:Susan Holmes and Wolfgang Huber
Publisher:Cambridge University Press
Edition:1
Costs:60.00

Instructional modes
Practical computer training
Attendance MandatoryYes

Team-Based Learning
Attendance MandatoryYes

Tests
Digi-Cirrus
Test weight3
Test typeDigital exam with CIRRUS
OpportunitiesBlock KW3, Block KW4

Computer Practical Assignments
Test weight3
Test typeAssignment
OpportunitiesBlock KW3, Block KW4

Group Work Assignments
Test weight4
Test typeAssignment
OpportunitiesBlock KW3