NWI-LM011
Metabolism, Transport and Motility
Course infoSchedule
Course moduleNWI-LM011
Credits (ECTS)3
CategoryMA (Master)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; Moleculaire Wetenschappen;
Lecturer(s)
PreviousNext 2
Lecturer
prof. dr. P.M.T. Deen
Other course modules lecturer
Lecturer
L. Kluijtmans
Other course modules lecturer
Lecturer
prof. dr. ir. M.M. Verbeek
Other course modules lecturer
Lecturer
dr. D.G. Wansink
Other course modules lecturer
Coordinator
dr. ing. M.J.G. Wilmer
Other course modules lecturer
Academic year2017
Starting block
KW1
Course mode
full-time
Remarksfinal resit
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims

At the end of this course, you will be familiar with the biomedical significance of metabolites and biomolecules in molecular life sciences. Emphasis will be put on integration of compounds in the larger cellular network associated with metabolism, transport and motility under physiological and pathological conditions.

At the end of the course, you are able to:

  • appreciate the significance of ‘metabolic, transport and motion research’ in molecular life sciences
  • and medicine
  • describe molecular mechanisms in pathologic conditions
  • use modern technologies to design and study molecular therapeutic strategies
  • implement the newly obtained knowledge to design future applied and fundamental research
Content
You will be offered a comprehensive series of lectures on specific subjects in the field of molecular life sciences that go beyond basic (bachelor) knowledge of biochemistry and cell biology. You will read background literature and make yourself familiar with the significance of membrane transporters in drug disposition, metabolite profile analysis, water and electrolyte transport, mobility control, molecular pathology of trinucleotide disease involving intracellular processing and transport of RNA and protein.
These topics will be discussed in the context of multifactorial and multisystemic disorders, such as chronic kidney disease, Alzheimers disease, myotonic dystrophy, channelopathies, P-type ATPase related diseases. The value of multi-disciplinary approaches and state-of-the-art research methodologies will be discussed.
Literature
Literature assignments and hand-outs are distributed during the lectures

Teaching formats

• 1 hours groepsgewijs college
• 14 hours lecture
• 2 hours student presentation
• 5 hours problem session
• 58 hours individual study period
Extra information teaching methods: Two week full time masters course with (interactive) lectures and self study assignments. Attending lectures and tutors session are highly recommended, as basic knowledge will be extended with a review of the latest literature and no textbook is available. In addition, two topics form the basis for oral or written student presentations and a pro/con-debate. Attending and preparing your own student presentation will be part of your final grade.

Topics
• The essence of metabolic investigations
• Multifactorial disorders
• Coupling of energy/redox metabolism to cell viability and renal water and electrolyte transport
• Biochemical adaptation to energy and redox stress
• ABC transporters and solute carriers
• Function of drug transporters in health and disease
• Intracellular processing and transport of RNA and protein in myotonic dystrophy
• P-type ATPases related diseases
• Fluid flow and transport mechanisms in the brain and in Alzheimer’s disease

The course will focus on different aspects of metabolism, transport and motility in muscle, brain, kidney disease and cancer and other health problems.

Test information
Grade for presentation/report and Written examination

Prerequisites
Biochemie - moleculaire biologie II (NWI-BB017C) and Celbiologie der dieren (NWI-BB023B), both courses recommended.This is a course in the specialisation 'Clinical biology'.

Required materials
To be announced
Literature assignments and hand-outs are distributed during the lectures

Instructional modes
Lecture

Presentation
Attendance MandatoryYes

Zelfstudie
Attendance MandatoryYes

Tests
Tentamen
Test weight1
OpportunitiesBlock KW1

Remark
final resit