NWI-MOL001A
Chemical Analysis
Course infoSchedule
Course moduleNWI-MOL001A
Credits (ECTS)3
CategoryPB (Propaedeutic)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; Moleculaire Wetenschappen;
Lecturer(s)
Coordinator
dr. T.G. Bloemberg
Other course modules lecturer
Examiner
dr. T.G. Bloemberg
Other course modules lecturer
Contactperson for the course
dr. T.G. Bloemberg
Other course modules lecturer
Lecturer
dr. T.G. Bloemberg
Other course modules lecturer
Lecturer
drs. L.T.C.G. van Summeren
Other course modules lecturer
Academic year2018
Period
KW1  (03/09/2018 to 04/11/2018)
Starting block
KW1
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesNo
Pre-registrationNo
Waiting listNo
Placement procedure-
Aims
After this course you are able to individually:
  • explain - at a basic level - the interactions of electromagnetic radiation from the UV-VIS range with atoms and molecules and exploit these in simple quantitative spectroscopic analyses.
  • explain - at a basic level - the principles of chromatographic separation and detection techniques and use this knowledge to perform and optimize a basic chromatographic experiment.
  • design and quantitatively perform a simple calibration experiment and critically interpret its results using the appropriate statistical methods.
  • make an informed estimation of the risks of simple experiments in a chemical laboratory and perform the experiments in a safe way.
  • prepare a simple experiment and keep a proper laboratory notebook.
Content
Modern chemical analysis makes use of advanced instrumentation, based on several chemical and physical principles. The theoretical part of this course will treat some of the underlying principles and consequences of measurement methods, both quantitative and qualitative. Chromatographic separation methods and spectroscopic analysis cover a significant part of the field. In this course, atomic and molecular UV-VIS spectroscopy and chromatographic separation techniques will be treated. Attention will be paid to the reliability of measurement results, based on elementary statistical and chemometrical principles.
 
The practical part of the course is aimed at strengthening, applying and extending the knowledge obtained in the theoretical part and at making a start with acquiring the laboratory skills of a molecular scientist. At the start of the course, the focus wil be on attaining a number of basic skills (weighing, pipetting, titration, making a dilution series, etc.). Later on, these skills will be applied in experiments of one day in which simple chemical analyses are conducted. Apart from that, much attention will be given to preparing experiments, record-keeping in laboratory notebooks, error analyses and - importantly - knowledge of safety rules. The latter will be tested in a digital test at the beginning of the course.
Additional comments
You are obliged to:

• hand in / have handed in a digital passport photo of yourself (mentioning your first and last names) on the first day of the lab course, if one is not (yet) available from Osiris;
• possess a durable laboratory notebook (bound and with a hard cover; can be bought via the education institute);
• possess a white labcoat of non-synthetic fiber (can be bought via the education institute);
• possess proper safety glasses (can be bought via the education institute);
• possess a dish cloth / tea towel for drying glassware (can be bought via the education institute).

Topics
• basic statistical concepts (accuracy, precision, confidence interval, linear regression, error propagation);
• UV-VIS atomic and molecular spectroscopy;
• extraction techniques;
• chromatography, general principles;
• gas chromatography (GC);
• liquid chromatography / HPLC;
• hybrid methods (GC-MS, LC-MS).

Test information
Safety test: At the beginning of the course, you are required to have familiarized yourself with the safety rules and guidelines that are detailed in the laboratory manual and in the safety lecture in the first week. This will be tested in a digital safety test. Failing this test and the resit means you are prohibited from being in the lab.

Practical part:
The final assessment of the practical part is based on:

• your practical skills and adherence to lab rules, as observed by supervisors and TA's (25%)
• the quality of registration and interpretation of experimental results in your lab notebook (25%)
• the quality of your writing assignments (25%)
• the results you obtain in the final practical assessment, the so-called 'aptitude test' (25%).

The sub-grade for practical skills and rule adherence should be 5 or higher. A lower grade means that the grade for the entire practical part will not be higher than 5.

Theory part:
The theory part is concluded with a digital exam.

Grading:
All grading is on a scale of 1 to 10. The final grade is rounded to the nearest half, with the exception of grades between 5.0 and 6.0 which are rounded to the nearest integer. Grades of 6 and higher are considered a 'pass' and grades lower than 6 are considered a 'fail'. When both the practical part and the theory part are graded with a 6 or higher, the final grade equals their average. Otherwise, the final grade equals the lower of the two.

A 'fail' for the theory part means that a resit is required; a 'fail' for the practical part means that a fully repeated participation in the practical part in the next academic year is, in principle, required. An exception can be made for students that failed the aptitude test and / or the writing assignments. These students can be eligible for a one-day resit of the aptitude test for which both the new aptitude test and a writing assignment can be graded. Students are only eligible for this when it is practically possible for them to pass the lab course by receiving higher sub-grades for the aptitude test and / or the writing assignments.

Prerequisites
• Chemistry at the level of Dutch pre-university secondary education ('VWO') or comparable
• English language
This is a course in the theme 'Methods' and in the theme 'Lab and research skills'

Contact information
Dr. T. G. Bloemberg
Lab Coordinator
Education Institute for Molecular Sciences
Radboud University

Heyendaalseweg 135
6525 AJ Nijmegen
Room Hg01.544

Tel: +31(0)24 36 53452
E-mail: t.bloemberg@science.ru.nl

Required materials
Course guide
Laboratory manual (for sale at the university in the first week of the academic year)
Book
D.C. Harris, Exploring Chemical Analysis, 5th ed., 2013, W.H. Freeman and Company, New York
ISBN:9781429275033
Book
T. Overton, S. Johnson, J. Scott: Study and communication skills for the chemical sciences, Oxford University press, 2nd ed.
ISBN:9780198708698

Recommended materials
Book
Paula Y. Bruice, Organic Chemistry, Prentice Hall, 7th or 8th ed.
ISBN:9781292160344

Instructional modes
Lab course
Attendance MandatoryYes

Lecture

Practical computer training

Zelfstudie

Tests
Exam
Test weight1
Test typeDigital exam with CIRRUS
OpportunitiesBlock KW1, Block KW2

Lab
Test weight1
Test typeLab course
OpportunitiesBlock KW1, Block KW2