Toxicology ("science of poisons") focuses on studying the harmful effects of substances on living organisms. The aim is to assess and minimize undesirable effects the risks of exposure to these substances to humans, animals and the environment. Toxicology is an interdisciplinary science that studies the mechanism of poisoning, making use of chemistry, biology, genetics, physiology and medicine. In this course the student will understand basic concepts of toxicology, such as exposure, dose-response relationships, biotransformation, and kinetics.
In addition, the molecular mechanisms and problems of some specific groups of contaminants (eg pesticides, stimulants, natural toxins, PAHs, PCBs and dioxins) will be addressed. Moreover, the mechanisms of toxicity on organ systems such as liver, kidney, lungs, blood, reproductive organs, and the central and peripheral nervous system will be discussed. During the course the students will use "the expert knowledge base" system (Derek) that predicts the toxicity based on structural properties of compounds.