NWI-MOL055
Molecular Basis of Diseases
Course infoSchedule
Course moduleNWI-MOL055
Credits (ECTS)6
CategoryBA (Bachelor)
Language of instructionEnglish
Offered byRadboud University; Faculty of Science; Moleculaire Wetenschappen;
Lecturer(s)
PreviousNext 5
Lecturer
dr. M. Ansems
Other course modules lecturer
Lecturer
prof. dr. R.E. Brock
Other course modules lecturer
Coordinator
dr. A.P.M. de Brouwer
Other course modules lecturer
Examiner
dr. A.P.M. de Brouwer
Other course modules lecturer
Contactperson for the course
dr. A.P.M. de Brouwer
Other course modules lecturer
Academic year2019
Period
KW3-KW4  (03/02/2020 to 30/08/2020)
Starting block
KW3
Course mode
full-time
Remarks-
Registration using OSIRISYes
Course open to students from other facultiesYes
Pre-registrationNo
Waiting listYes
Placement procedure-
Aims
At the end of the course the student is able to:
  • describe molecular processes that are involved in health and disease and potential options for therapy.
  • select diagnostic techniques and research approaches, which currently are used to detect molecular defects to identify the molecular basis of the resulting disorders.
  • prepare an essay on a contemporary hot topic.
Content
In this course, the students will be introduced to molecular mechanisms of disease for a number of genetic, immunologic and metabolic disorders. As such, the course is divided into three parts: human molecular genetics, immunology, and metabolism. In every part, researchers will present disease-related topics that are closely related to their own research. Often, there is a direct relation between a disorder and a genetic defect. In other cases, such as in many immunological disorders, profound knowledge on the underlying molecular processes is required, even though there may still be a genetic predisposition.
In comparison to other courses, this course is not textbook-based and also less coherent, but instead presents state-of-the-art research results on a selection of highly relevant topics. Ultimately, the students will obtain an idea on the diversity of the molecular mechanisms underlying various pathologies and potential therapeutic approaches. Diagnostic techniques and analytical methods will be introduced as part of the lectures and during practical demonstrations. Where required, fundamental background knowledge will be introduced.
The preparation of an essay and a presentation about one topic is an important element of the course. The presentations will be given towards the end of the course. Both essay and presentation are prepared in the same focus group of three students. The topics directly relate to one of the main themes of the course.
Presence is obligatory during the non-computer practicals, the presentations and the exam. However, presence during lectures, feedback sessions, and computer practicals is strongly recommended as this course is not textbook-based. Therefore, students will benefit from maximum contact with the lecturers. Handouts of all lectures are provided via Brightspace and all lectures will be recorded.
Level

Presumed foreknowledge
The course focusses on molecular processes in relation to disorders. Fundamental knowledge of (bio-)chemical reactions and metabolic pathways is therefore required.This is a course in the programme 'Molecular Life Sciences'.
Test information
Knowledge of the content of the lectures will be tested in an exam. The questions focus on principles and understanding. The exam will contribute 75% to the final grade and the essay 25%. For each part, at least a 5.5 is required in order to pass the course.
Specifics

Test information
Knowledge of the content of the lectures will be tested in an exam. The questions focus on principles and understanding. The exam will contribute 75% to the final grade and the essay 25%. For each part, at least a 5.5 is required in order to pass the course.

Prerequisites
The course focusses on molecular processes in relation to disorders. Fundamental knowledge of (bio-)chemical reactions and metabolic pathways is therefore required.This is a course in the programme 'Molecular Life Sciences'.

Required materials
Blackboard
The required materials are provided in the form of publications, copies from textbooks, Power Point presentations and video recordings on Blackboard.

Instructional modes
Exam Q4

Lab course
Attendance MandatoryYes

Lecture

Practical computer training
Attendance MandatoryYes

Resit Exam Q4

Response course

Tests
Exam
Test weight7
Test typeExam
OpportunitiesBlock KW3, Block KW4

Essay
Test weight3
Test typeEssay
OpportunitiesBlock KW3, Block KW4