At the end of the course the student is able to:

• describe molecular processes that are involved in health and disease and potential options for molecular therapy.
• select diagnostic techniques and research approaches, which currently are used to detect molecular defects to identify the molecular basis of the resulting disorders.
• prepare an essay about a contemporary hot topic.

In this course, the students will be introduced to molecular mechanisms of disease for a number of genetic, immunologic and metabolic disorders. As such, the course is divided into three parts: human molecular genetics, immunology, and metabolism. In every part, researchers will present disease-related topics that are closely related to their own research. Often, there is a direct relation between a disorder and a genetic defect. In other cases, such as in many immunological disorders, profound knowledge on the underlying molecular processes is required, even though there may still be a genetic predisposition to these disorders.

In comparison to other courses, this course is not textbook-based and also less coherent, but instead presents state-of-the-art research results on a selection of highly relevant topics. Ultimately, the students will obtain an idea on the diversity of the molecular mechanisms underlying various pathologies and potential therapeutic approaches. Diagnostic techniques and analytical methods will be introduced as part of the lectures and during practical demonstrations. Where required, fundamental background knowledge will be introduced.

The preparation of an essay about one topic is an important element of the course. The topics directly relate to one of the main themes of the course. Presence is not obligatory throughout the course. However, presence during lectures, feedback sessions, and computer practicals is strongly recommended as this course is not textbook-based. Therefore, students will benefit from maximum contact with the lecturers. Handouts of all lectures are provided via Brightspace and all lectures will be recorded.