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After the course, you are able to:
- design conceptually different approaches to create stereochemically pure products (diastereoisomers and enantiomers),
- explain the different forms of stereoselectivity (enantio- and diastereoselectivity) in chemical reactions,
- formulate reaction sequences for the stereoselective synthesis of specific small molecules,
- describe chirality and stereoisomerism in detail.
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The course 'Stereoselective Synthesis' builds upon the conceptual approach of the courses 'Organic Chemistry 1' (NWI-MOL124) and 'Organic Chemistry' (NWI-MOL095) by focussing on the stereoselective aspects of chemical transformations. Based on the knowledge of reaction mechanisms, the stereochemical course of reactions can be often predicted leading to highly enantioselective, diastereoselective, and/or regioselective processes. In this course, students will become acquainted with various aspects of stereochemistry, their role in chemical processes, and their importance in society.
Topics:
- Stereochemistry and reactions of enolates
- Stereoselective reactions of olefins
- Stereoselectivity in cyclic molecules
- Diastereoselectivity in addition reactions to aldehydes and ketones and in the aldol reaction
- Pericyclic reactions: cycloadditions and [3,3] sigmatropic rearrangements
- Neighboring group participation, rearrangements and fragmentations
- Asymmetric synthesis strategies
Instructional Modes |
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Third-year course. Advanced.
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'Organic Chemistry 1' (NWI-MOL124) and 'Organic chemistry' (NWI-MOL095). This is a course in the theme 'Structure and Reactivity'.
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